{{Rsnum
|rsid=5082
|Gene=APOA2
|Chromosome=1
|position=161223893
|Orientation=minus
|GMAF=0.2521
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=APOA2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 17.7 | 43.4 | 38.9
| HCB | 1.5 | 18.2 | 80.3
| JPT | 0.0 | 8.0 | 92.0
| YRI | 4.8 | 41.5 | 53.7
| ASW | 3.5 | 45.6 | 50.9
| CHB | 1.5 | 18.2 | 80.3
| CHD | 0.0 | 16.5 | 83.5
| GIH | 4.0 | 36.6 | 59.4
| LWK | 2.8 | 19.3 | 78.0
| MEX | 0.0 | 50.0 | 50.0
| MKK | 0.0 | 16.7 | 83.3
| TSI | 16.7 | 45.1 | 38.2
| HapMapRevision=28
}}
[[rs5082]] is a SNP in the apolipoprotein [[APOA2]] gene, and may influence [[obesity]] and [[heart disease]] risk.

Individuals homozygous for the -265T>C polymorphism in [[rs5082]], i.e. individuals with the [[rs5082(C;C)]] genotype of the Apolipoprotein A-II gene ([[APOA2]]) promoter, are associated with increased [[obesity|Body Mass Index]] and food intake in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study of ~1000 individuals. The odds ratio for [[obesity]] in (C;C) individuals compared to [[rs5082]](T) allele carriers was 1.70 (CI: 1.02-2.80, p=0.039). Total energy, total fat, and total protein intake were all significantly higher in (C;C) individuals.{{PMID|17446329}}

In a separate study, a case-control analysis of 484 Australian male coronary artery disease patients concluded that [[rs5082]](C;C) individuals were at significantly lower risk for that form of [[heart disease]] than [[rs5082]](T) allele carriers (odds ratio 0.57, CI: 0.39-0.84, p=0.004).{{PMID|18179799}}

A meta-analysis of several [[APOA2]] SNPs (including this one) found no association between any APOA2 SNPs studied and type-2 diabetes.{{PMID|19216768|OA=1
}}

{{PMID|17709437}} An apolipoprotein A-II polymorphism (-265T/C, rs5082) regulates postprandial response to a saturated fat overload in healthy men.

{{PMID|18304332|OA=1
}} No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins.

[[Response to Diet and Exercise]]

{{PMID Auto
|PMID=24108135
|Title=Apolipoprotein A2 Polymorphism Interacts with Intakes of Dairy Foods to Influence Body Weight in Two U.S. Populations
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}