{{Rsnum
|rsid=509749
|Gene=LY9
|Chromosome=1
|position=160823770
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.3747
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=LY9
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 26.5 | 56.6 | 16.8
| HCB | 9.5 | 36.5 | 54.0
| JPT | 5.3 | 38.9 | 55.8
| YRI | 4.1 | 29.3 | 66.7
| ASW | 8.8 | 50.9 | 40.4
| CHB | 9.5 | 36.5 | 54.0
| CHD | 4.6 | 43.1 | 52.3
| GIH | 15.8 | 53.5 | 30.7
| LWK | 3.6 | 25.5 | 70.9
| MEX | 5.3 | 47.4 | 47.4
| MKK | 12.2 | 38.5 | 49.4
| TSI | 29.4 | 52.0 | 18.6
| HapMapRevision=28
}}[[rs509749]] is a SNP in exon 8 of the [[LY9]] gene; this SNP is also known as Met602Val. The (A) allele encodes the Met; the (G) allele encodes the Val.

The rarer (G) allele is undertransmitted in a family-based association study of systemic [[lupus]] erythematosus, leading to the conclusion that the (A) allele increases risk for [[SLE]] by increasing cytokine production and thereby enhancing the immune response.{{PMID|18216865}}

{{PMID Auto
|PMID=19714582
|Title=Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors
}}

{{PMID Auto
|PMID=19442287
|Title=Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=19838195
|Title=A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|OA=1
}}

{{GET Evidence
|gene=LY9
|aa_change=Met602Val
|aa_change_short=M602V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs509749
|overall_frequency_n=5746
|overall_frequency_d=10758
|overall_frequency=0.534114
|n_genomes=48
|n_genomes_annotated=0
|n_haplomes=71
|n_articles=0
|n_articles_annotated=0
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}