{{Rsnum
|rsid=5128
|Gene=APOC3
|Chromosome=11
|position=116832924
|Orientation=minus
|GMAF=0.191
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=APOC3
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 0.9 | 15.9 | 83.2
| HCB | 10.4 | 43.0 | 46.7
| JPT | 8.9 | 53.6 | 37.5
| YRI | 4.8 | 29.3 | 66.0
| ASW | 1.8 | 7.1 | 91.1
| CHB | 10.4 | 43.0 | 46.7
| CHD | 12.8 | 40.4 | 46.8
| GIH | 7.9 | 47.5 | 44.6
| LWK | 0.9 | 17.3 | 81.8
| MEX | 5.2 | 24.1 | 70.7
| MKK | 4.5 | 29.7 | 65.8
| TSI | 2.0 | 21.0 | 77.0
| HapMapRevision=28
}}

[[rs5128]] (C3238G/3238C>G) is a SNP within the 3' UTR of [[APOC3]] (Apolipoprotein C3).

{{PMID|19424489|OA=1
}} subjects with GC/GG genotypes and diabetes exhibited sig. higher triglyceride (p=0.004), total cholesterol (p=0.003) and glucose (p=0.016) compared to CC subjects

{{PharmGKB
|RSID=rs5128
|Name_s=APOC3: 3238 C>G
|Gene_s=APOA4, APOA1, APOC3
|Feature=Intron, Intron, 3' UTR
|Evidence=PubMed ID:15809899; PubMed ID:16417409; PubMed ID:17700364
|Annotation=This 3' UTR variant is associated with hyperlipidemia (elevated triglyceride levels) for HIV-infected individuals treated with ritonavir.
|Drugs=ritonavir
|Drug Classes=
|Diseases=HIV; HIV Infections; Hyperlipidemias
|Curation Level=Curated
|PharmGKB Accession ID=PA162359985
}}

{{PMID Auto
|PMID=22848358
|Title=Hypercholesterolemia Is Associated with the Apolipoprotein C-III (APOC3) Genotype in Children Receiving HAART: An Eight-Year Retrospective Study
|OA=1
}}

{{PMID Auto
|PMID=17357073
|Title=Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.
|OA=1
}}

{{PMID Auto
|PMID=18513389
|Title=New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
|OA=1
}}

{{PMID Auto
|PMID=18789138
|Title=The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides.
|OA=1
}}

{{PMID Auto
|PMID=18801202
|Title=Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease.
|OA=1
}}

{{PMID Auto
|PMID=19014573
|Title=Application of two machine learning algorithms to genetic association studies in the presence of covariates.
|OA=1
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19057464
|Title=Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=20406163
|Title=Fenofibrate and metabolic syndrome.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs5128
|overall_frequency_n=9555
|overall_frequency_d=10758
|overall_frequency=0.888176
|n_genomes=54
|n_genomes_annotated=0
|n_haplomes=89
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22924697
|Title=Interactions between the apolipoprotein a1/c3/a5 haplotypes and alcohol consumption on serum lipid levels.
}}

{{PMID Auto
|PMID=23021345
|Title=Gene-diet interactions on plasma lipid levels in the Inuit population.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}