{{Rsnum
|rsid=526934
|Gene=TCN1
|Chromosome=11
|position=59866020
|Orientation=plus
|GMAF=0.2176
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TCN1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 48.7 | 46.9 | 4.4
| HCB | 64.2 | 32.8 | 2.9
| JPT | 71.7 | 26.5 | 1.8
| YRI | 78.9 | 19.0 | 2.0
| ASW | 68.4 | 28.1 | 3.5
| CHB | 64.2 | 32.8 | 2.9
| CHD | 68.8 | 28.4 | 2.8
| GIH | 62.4 | 33.7 | 4.0
| LWK | 82.2 | 16.8 | 0.9
| MEX | 58.6 | 36.2 | 5.2
| MKK | 57.1 | 36.5 | 6.4
| TSI | 47.0 | 45.0 | 8.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19303062
|Trait=Folate pathway vitamins
|Title=Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations
|RiskAllele=A
|Pval=0.000002
|OR=27.62
|ORtxt=[11.65-43.59] pg/mL increase
|OA=1
}}Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. {{PMID|19744961|OA=1
}} G allele associated with lower serum Vitamin B12. "The TCN1 rs526934 G variant may reduce transport of cobalamin, resulting in lower plasma vitamin B12 levels."

{{PharmGKB
|RSID=rs526934
|Name_s=
|Gene_s=TCN1
|Feature=
|Evidence=PubMed ID:19303062; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations. (Initial Sample Size: 2,934 individuals; Replication Sample Size: 686 individuals); (Region: 11q12.1; Reported Gene(s): TCN1; Risk Allele: rs526934-A); (p-value= 0.000002).This variant is associated with Folate pathway vitamins.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739920
}}

{{PMID Auto
|PMID=17119116
|Title=Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study.
|OA=1
}}

{{PMID Auto
|PMID=19064790
|Title=Predictive genomics of cardioembolic stroke.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs526934
|overall_frequency_n=94
|overall_frequency_d=126
|overall_frequency=0.746032
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=82
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}