{{Rsnum
|rsid=5361
|Gene=SELE
|Chromosome=1
|position=169731919
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=C
|GMAF=0.0551
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=SELE
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 77.9 | 20.4 | 1.8
| HCB | 98.5 | 1.5 | 0.0
| JPT | 95.6 | 4.4 | 0.0
| YRI | 95.9 | 4.1 | 0.0
| ASW | 84.2 | 14.0 | 1.8
| CHB | 98.5 | 1.5 | 0.0
| CHD | 97.2 | 2.8 | 0.0
| GIH | 81.2 | 16.8 | 2.0
| LWK | 95.5 | 4.5 | 0.0
| MEX | 89.7 | 10.3 | 0.0
| MKK | 98.1 | 1.9 | 0.0
| TSI | 79.4 | 20.6 | 0.0
| HapMapRevision=28
}}The [[rs5361]] Ser128Arg variation in this gene, known as E-selectin, is linked to several thrombotic disorders.

[[rs5361(C;C)]] homozygous carriers of the Ser128Arg allele are at a 4X higher risk for recurrent [[venous thromboembolism]] (VTE); heterozygous carriers are not at increased risk. {{PMID|16908800}}.

{{PMID Auto
|PMID=22589243
|Title=Association of E-selectin gene polymorphisms with ischemic stroke in a Chinese Han population
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=16820586
|Title=Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
|OA=1
}}

{{PMID Auto
|PMID=17327408
|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=18513389
|Title=New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
|OA=1
}}

{{PMID Auto
|PMID=18633131
|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
|PMID=19066394
|Title=Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=20622166
|Title=Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study.
|OA=1
}}

{{PMID Auto
|PMID=22116284
|Title=A two-step genetic study on quantitative precursors of coronary artery disease in a homogeneous Indian population: case-control association discovery and validation by transmission-disequilibrium test.
}}

{{PMID Auto
|PMID=22388798
|Title=Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.
|OA=1
}}

{{PMID Auto
|PMID=22414298
|Title=Lack of an association between E-selectin gene polymorphisms and risk of Kawasaki disease.
}}

{{GET Evidence
|gene=SELE
|aa_change=Ser149Arg
|aa_change_short=S149R
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs5361
|overall_frequency_n=899
|overall_frequency_d=10758
|overall_frequency=0.0835657
|n_genomes=2
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.978
|nblosum100=3
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=21780194
|Title=E-selectin rs5361 and FCGR2A rs1801274 variants were associated with increased risk of gastric cancer in a Chinese population.
}}

{{PMID Auto
|PMID=23274712
|Title=Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age.
|OA=1
}}

{{PMID Auto
|PMID=23533563
|Title=Novel risk factors for premature peripheral arterial occlusive disease in non-diabetic patients: a case-control study.
|OA=1
}}

{{PMID Auto
|PMID=23772946
|Title=Association of cell adhesion molecule gene polymorphisms with recurrent aphthous stomatitis.
}}

{{PMID Auto
|PMID=25091233
|Title=Association of F11 polymorphism rs2289252 with deep vein thrombosis and related phenotypes in population of Latvia
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}