{{Rsnum
|rsid=540825
|Gene=OPRM1
|Chromosome=6
|position=154093311
|Orientation=minus
|GMAF=0.1263
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=OPRM1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 58.5 | 40.0 | 1.5
| HCB | 95.6 | 4.4 | 0.0
| JPT | 79.5 | 20.5 | 0.0
| YRI | 90.5 | 9.5 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 95.6 | 4.4 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

[http://www.psychiatrictimes.com/display/article/10168/1153657 Psychiatric Times] 
This SNP is located in an alternatively spliced exon of the OPRM1 gene and is found only in the MOR1X isoform. Preliminary data suggest that when expressed in cultured cells, this isoform differs significantly from the typical MOR1 isoform in its regulation by membrane trafficking (M. Tanowitz, M. von Zastrow, personal oral communication, 2008).

{{PMID Auto
|PMID=15558714
|Title=Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence.
}}

{{PMID Auto
|PMID=19053977
|Title=OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach.
|OA=1
}}

{{PMID Auto
|PMID=19103668
|Title=Expansion of the human mu-opioid receptor gene architecture: novel functional variants.
|OA=1
}}

{{PMID Auto
|PMID=20194481
|Title=Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder.
|OA=1
}}

{{GET Evidence
|gene=OPRM1
|aa_change=Gln402His
|aa_change_short=Q402H
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs540825
|overall_frequency_n=8174
|overall_frequency_d=9966
|overall_frequency=0.820189
|n_genomes=55
|n_genomes_annotated=0
|n_haplomes=97
|n_articles=0
|n_articles_annotated=0
|nblosum100=-1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23144877
|Title=A Non-Synonymous Single Nucleotide Polymorphism in an OPRM1 Splice Variant Is Associated with Fentanyl-Induced Emesis in Women Undergoing Minor Gynaecological Surgery
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}