{{Rsnum
|rsid=543749
|Gene=ADAM33
|Chromosome=20
|position=3669032
|Orientation=plus
|GMAF=0.1749
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=ADAM33
}}[[rs543749]], also known as IVS21_22 or V-1, is a SNP in the ADAM metallopeptidase domain 33 [[ADAM33]] gene.

A study of ~600 non-Hispanic white males who smoked concluded that [[rs543749]](G;G) carriers, i.e. those homozygous for the most common allele, were more likely (p< 0.0026, after Bonferroni correction) to develop [[chronic obstructive pulmonary disease]] (COPD) than carriers of one or two [[rs543749]](T) alleles.{{doi|10.1186/1465-9921-10-21}}

{{PMID Auto
|PMID=17878941
|Title=ADAM33, a new candidate for psoriasis susceptibility.
|OA=1
}}

{{PMID Auto
|PMID=18560587
|Title=Replication of association between ADAM33 polymorphisms and psoriasis.
|OA=1
}}

{{PMID Auto
|PMID=19284602
|Title=Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers.
|OA=1
}}

{{PMID Auto
|PMID=21320344
|Title=Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
|OA=1
}}

{{PMID Auto
|PMID=23380143
|Title=A disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and the risk of asthma: a meta-analysis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}