{{Rsnum
|rsid=5446
|Gene=GNB3
|Chromosome=12
|position=6847298
|Orientation=plus
|GMAF=0.3076
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=GNB3
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 40.7 | 51.3 | 8.0
| HCB | 66.4 | 30.7 | 2.9
| JPT | 73.5 | 24.8 | 1.8
| YRI | 32.9 | 45.9 | 21.2
| ASW | 28.1 | 42.1 | 29.8
| CHB | 66.4 | 30.7 | 2.9
| CHD | 58.7 | 39.4 | 1.8
| GIH | 42.6 | 51.5 | 5.9
| LWK | 34.5 | 49.1 | 16.4
| MEX | 51.7 | 37.9 | 10.3
| MKK | 32.7 | 37.2 | 30.1
| TSI | 43.1 | 48.0 | 8.8
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs5446
|Name_s=GNB3:1429C>T
|Gene_s=USP5, GNB3, CDCA3
|Feature=
|Evidence=PubMed ID:15226674; PubMed ID:15996174; PubMed ID:16713434
|Annotation=Associated with blood pressure and hypercholesterolemia but not hypertension.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145079
}}

{{PMID Auto
|PMID=18656447
|Title=Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM.
}}

{{PMID Auto
|PMID=19406964
|Title=Association of genetic variants with chronic kidney disease in Japanese individuals.
|OA=1
}}

{{PMID Auto
|PMID=19574959
|Title=Novel genetic variants in the alpha-adducin and guanine nucleotide binding protein beta-polypeptide 3 genes and salt sensitivity of blood pressure.
|OA=1
}}

{{PMID Auto
|PMID=20386734
|Title=Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs5446
|overall_frequency_n=36
|overall_frequency_d=128
|overall_frequency=0.28125
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=30
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}