{{Rsnum
|rsid=547154
|Gene=C2
|Chromosome=6
|position=31943161
|Orientation=minus
|GMAF=0.09963
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=C2,LOC102060414
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 0.0 | 12.4 | 87.6
| HCB | 0.0 | 10.9 | 89.1
| JPT | 2.7 | 10.7 | 86.6
| YRI | 2.0 | 21.8 | 76.2
| ASW | 0.0 | 28.1 | 71.9
| CHB | 0.0 | 10.9 | 89.1
| CHD | 0.9 | 5.5 | 93.6
| GIH | 2.0 | 30.7 | 67.3
| LWK | 2.7 | 33.6 | 63.6
| MEX | 0.0 | 13.8 | 86.2
| MKK | 0.6 | 20.5 | 78.8
| TSI | 1.0 | 12.7 | 86.3
| HapMapRevision=28
}}

{{PMID|18493315|OA=1
}} rs547154 significantly associated with Age-related maculopathy in both our case-control (P-value 0.00007) and family data (P-value 0.00001).

{{PMID Auto
|PMID=19399715
|Title=Impact of interacting functional variants in COMT on regional gray matter volume in human brain
}}

{{omim
|id=217000
|desc=COMPLEMENT COMPONENT 2 DEFICIENCY
|rsnum=547154
}}
{{PMID Auto
|PMID=19556007
|Title=Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiology
}}

{{omim
|id=217000
|rsnum=547154
|variant=0005
}}

{{PMID Auto
|PMID=22440158
|Title=CFB/C2 Gene Polymorphisms and Risk of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis
}}

{{PMID Auto
|PMID=22509112
|Title=Genetic associations in polypoidal choroidal vasculopathy: A systematic review and meta-analysis
|OA=1
}}

{{PMID Auto
|PMID=17576744
|Title=Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration.
}}

{{PMID Auto
|PMID=17917691
|Title=Genetic markers and biomarkers for age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=18806293
|Title=Analysis of rare variants in the complement component 2 (C2) and factor B (BF) genes refine association for age-related macular degeneration (AMD).
}}

{{PMID Auto
|PMID=18806297
|Title=Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration.
}}

{{PMID Auto
|PMID=19169411
|Title=Common variation in the SERPING1 gene is not associated with age-related macular degeneration in two independent groups of subjects.
|OA=1
}}

{{PMID Auto
|PMID=19259132
|Title=Multilocus analysis of age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=19696172
|Title=The involvement of complement factor B and complement component C2 in an Indian cohort with age-related macular degeneration.
}}

{{PMID Auto
|PMID=20157352
|Title=Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population.
|OA=1
}}

{{PMID Auto
|PMID=20378180
|Title=Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy.
|OA=1
}}

{{PMID Auto
|PMID=21609242
|Title=Age-related macular degeneration-susceptibility single nucleotide polymorphisms in a han chinese control population.
}}

{{PMID Auto
|PMID=22232432
|Title=Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population.
}}

{{PMID Auto
|PMID=22273503
|Title=Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population.
}}

{{PMID Auto
|PMID=23582991
|Title=Genetic Influences on the Outcome of Anti-Vascular Endothelial Growth Factor Treatment in Neovascular Age-related Macular Degeneration
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}