{{Rsnum
|rsid=5491
|Gene=ICAM1
|Chromosome=19
|position=10274864
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=T
|GMAF=0.07484
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=ICAM1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 100.0 | 0.0 | 0.0
| HCB | 86.7 | 11.1 | 2.2
| JPT | 88.6 | 11.4 | 0.0
| YRI | 55.6 | 39.7 | 4.8
| ASW | 0.0 | 0.0 | 0.0
| CHB | 86.7 | 11.1 | 2.2
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
{{PMID Auto
|PMID=19332210
|Title=Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups: Data from the Women's Genome Health Study
|OA=1
}}

{{PMID Auto
|PMID=18420209
|Title=ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: the multi-ethnic study of atherosclerosis (MESA)
|OA=1
}}

{{omim
|id=147840
|rsnum=5491
|variant=0001
}}

{{PMID Auto
|PMID=21392767
|Title=Polymorphisms in the ICAM1 gene predict circulating soluble intercellular adhesion molecule-1(sICAM-1)
|OA=1
}}

{{ClinVar
|rsid=5491
|Reversed=0
|FwdREF=A
|FwdALT=T
|REF=A
|ALT=T
|RSPOS=10385540
|CHROM=19
|GMAF=0.0751
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x05036800000015051f110101
|GENEINFO=ICAM1:3383
|GENE_NAME=ICAM1
|GENE_ID=3383
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.10385540A>T
|CLNORIGIN=1
|CLNSIG=255
|Tags=PM;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.9252; 0.07484
|CLNACC=RCV000015768.2
|CLNDBN=Malaria, cerebral, susceptibility to
|CLNDSDB=MedGen
|CLNDSDBID=C1855457
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=147840.0001
|COMMON=1
|Disease=Malaria
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=16625213
|Title=ICAM1 amino-acid variant K469E is associated with paediatric bronchial asthma and elevated sICAM1 levels.
}}

{{PMID Auto
|PMID=16642433
|Title=Polymorphism in maternal LRP8 gene is associated with fetal growth.
|OA=1
}}

{{PMID Auto
|PMID=17327408
|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=17668374
|Title=Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants.
|OA=1
}}

{{PMID Auto
|PMID=17903293
|Title=Genome-wide association with select biomarker traits in the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=18045607
|Title=Circulating soluble ICAM-1 levels shows linkage to ICAM gene cluster region on chromosome 19: the NHLBI Family Heart Study follow-up examination.
|OA=1
}}

{{PMID Auto
|PMID=18528404
|Title=Variation in the ICAM1 gene is not associated with severe malaria phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=18604267
|Title=Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.
|OA=1
}}

{{PMID Auto
|PMID=18633131
|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
|PMID=19055786
|Title=Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India.
|OA=1
}}

{{PMID Auto
|PMID=19066394
|Title=Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=20031567
|Title=An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=20494378
|Title=Association between functional variants of the ICAM1 and CRP genes and metabolic syndrome in Taiwanese subjects.
}}

{{GET Evidence
|gene=ICAM1
|aa_change=Lys56Met
|aa_change_short=K56M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs5491
|overall_frequency_n=803
|overall_frequency_d=10758
|overall_frequency=0.0746421
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=13
|n_articles=0
|n_articles_annotated=0
|nblosum100=4
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23114149
|Title=[Effects of ICAM-1 Gene K469E, K56M Polymorphisms on Plasma sICAM-1 Expression Levels in Chinese Yugur, Tibetan and Han Nationalities]
}}

{{PMID Auto
|PMID=24069166
|Title=Combined effects of icam-1 single-nucleotide polymorphisms and environmental carcinogens on oral cancer susceptibility and clinicopathologic development
|OA=1
}}

{{PMID Auto
|PMID=24955718
|Title=Interaction of Intercellular Adhesion Molecule 1 (ICAM1) Polymorphisms and Environmental Tobacco Smoke on Childhood Asthma
}}

{{PMID Auto
|PMID=25003170
|Title=Interaction of intercellular adhesion molecule 1 (ICAM1) polymorphisms and environmental tobacco smoke on childhood asthma
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}