{{Rsnum
|rsid=55705857
|Chromosome=8
|position=129633446
|Orientation=plus
|GMAF=0.02663
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}[[rs55705857]] is a SNP located in a relatively gene-poor area of chromosomal region 8q24.21, near other SNPs that have been associated with certain cancers (prostate and ovarian).

A study {{PMID|22922872|OA=1
}} by UCSF and Mayo Clinic researchers of over 1,600 glioblastoma patients concluded that carriers of a [[rs55705857]](G) allele are at 5 - 6 fold higher risk for developing a [[glioma]] disease subtype categorized by harboring IDH1 or IDH2 (somatic) mutations (for example, with oligodendrogliomas, the odds ratio was 6.3, CI 4.6–8.8, p = 2.2 × 10e−28). These risk factors are among the highest ever reported for cancer-associated SNPs found in a SNP survey; nonetheless, keep in mind that glioblastomas are quite rare, with on average 2 - 3 people per 100,000 diagnosed per year, even with an allele frequency for [[rs55705857]](G) of between 2 - 8%.

See also: http://www.genengnews.com/gen-news-highlights/gene-variant-raises-brain-tumor-risk/81247234/
{{PMID Auto
|PMID=23361564
|Title=Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology
|OA=1
}}
{{PMID Auto
|PMID=23399484
|Title=Deciphering the 8q24.21 association for glioma
}}{{PMID Auto
|PMID=23733245
|Title=Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis.
}}
{{PMID Auto
|PMID=25165198
|Title=Mutation-based molecular glioma classification: prevalence and association with germline risk snps
}}
{{PMID Auto
|PMID=25165335
|Title=Beneficial outcomes after pcv plus rt in oligodendroglial tumors are associated with detection or risk of an idh mutation
}}