{{Rsnum
|rsid=56411402
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|Chromosome=7
|position=99665237
|Gene=CYP3A5
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=CYP3A5,ZSCAN25
}}Cytochrome P450 3A ([[CYP3A]]) family of isoenzymes are responsible for metabolizing over half of prescribed drugs, thus determining absence of [[CYP3A]] expression is important for optimizing medical treatments. CYP3A5*4 is a rare variant in Chinese, Caucasians and Indians which may therefore not warrant screening for. {{PMID|12324482}}

At least one CYP3A5*1 [[allele]] is needed for expressing [[CYP3A5]] protein, with normal levels up to half of [[CYP3A]] present in the liver. Allele variant *4 is identified by [[rs56411402]] (14665A > G, p.Gln200Arg or Q200R) in exon 8. {{PMID|11279519}} Note the reverse orientation; the most common form of this SNP is [[rs56411402]](T), which is the same as '14665A' in publications.

The [[rs56411402]](C) allele defines the CYP3A5*4 variant, which is nonfunctional.

{{PMID|24699256|OA=1
}} Differential expression of cytochrome p450 enzymes in normal and tumor tissues from childhood rhabdomyosarcoma.

{{PMID|24604039|OA=1
}} Distribution of genetic polymorphisms of genes encoding drug metabolizing enzymes & drug transporters -- a review with Indian perspective.

{{PMID|21265876}} Genetic polymorphisms of drug-metabolizing phase I enzymes CYP2E1, CYP2A6 and CYP3A5 in South Indian population.

{{PMID|12433824}} Pharmacokinetics of midazolam and 1'-hydroxymidazolam in Chinese with different CYP3A5 genotypes.

{{PMID|12324482}} CYP3A5 variant allele frequencies in Dutch Caucasians.

{{PMID|11502729}} Genetic polymorphism of cytochrome P450 3A5 in Chinese.

{{PMID|11279519}} Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}