{{Rsnum
|rsid=564398
|Gene=CDKN2BAS
|Chromosome=9
|position=22029548
|Orientation=minus
|GMAF=0.2048
|Gene_s=CDKN2B-AS1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 33.6 | 46.0 | 20.4
| HCB | 83.9 | 15.3 | 0.7
| JPT | 78.8 | 18.6 | 2.7
| YRI | 100.0 | 0.0 | 0.0
| ASW | 93.0 | 7.0 | 0.0
| CHB | 83.9 | 15.3 | 0.7
| CHD | 77.1 | 21.1 | 1.8
| GIH | 44.6 | 44.6 | 10.9
| LWK | 98.2 | 1.8 | 0.0
| MEX | 74.1 | 24.1 | 1.7
| MKK | 94.2 | 5.8 | 0.0
| TSI | 37.3 | 51.0 | 11.8
| HapMapRevision=28
}}

[http://suicyte.wordpress.com/2007/05/28/soul-searching-ii/ part 2] in the series mentions [[rs564398 ]]

{{PMID Auto GWAS
|PMID=17463249
|Trait=Type 2 diabetes
|Title=Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
|RiskAllele=T
|Pval=9.9999999999999995E-8
|OR=1.12
|ORtxt=[1.07-1.17]
|OA=1
}}

{{PharmGKB
|RSID=rs564398
|Name_s=
|Gene_s=CDKN2BAS
|Feature=
|Evidence=PubMed ID:17463249
|Annotation=rs564398 is associated with susceptibility to Type 2 Diabetes. The association has been noted in two case-control studies of UK subjects as well as in another large case-control study.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162191338
}}
{{PMID Auto
|PMID=20043145
|Title=Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
|OA=1
}}

{{PMID Auto
|PMID=20616309
|Title=Coronary Artery Calcification and Its Relationship to Validated Genetic Variants for Diabetes Mellitus Assessed in the Heinz Nixdorf Recall Cohort
}}

{{PMID Auto
|PMID=21315566
|Title=Type 2 diabetes and polymorphisms on chromosome 9p21: A meta-analysis
}}

{{PMID Auto
|PMID=21414664
|Title=A polymorphism in the chromosome 9p21 ANRIL locus is associated to Philadelphia positive acute lymphoblastic leukemia
}}

{{PMID|17786212|OA=1
}} Heterogeneity in meta-analyses of genome-wide association investigations.

{{PMID|18368387}} Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids.

{{PMID|18426861|OA=1
}} Association analysis of type 2 diabetes Loci in type 1 diabetes.

{{PMID|18443202|OA=1
}} Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.

{{PMID|18461161|OA=1
}} Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.

{{PMID|18469204|OA=1
}} Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.

{{PMID|18533027|OA=1
}} Worldwide population differentiation at disease-associated SNPs.

{{PMID|18591388|OA=1
}} Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

{{PMID|18633108|OA=1
}} Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

{{PMID|18694974|OA=1
}} Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.

{{PMID|18852197|OA=1
}} Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.

{{PMID|19002430}} Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.

{{PMID|19056611|OA=1
}} Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.

{{PMID|19279076|OA=1
}} Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men.

{{PMID|19341491|OA=1
}} Genome-based prediction of common diseases: methodological considerations for future research.

{{PMID|19343170|OA=1
}} INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis.

{{PMID|19475673|OA=1
}} Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke.

{{PMID|19862325|OA=1
}} PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.

{{PMID|19931040|OA=1
}} Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.

{{PMID|20017978|OA=1
}} Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.

{{PMID|20018066|OA=1
}} Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study.

{{PMID|20386740|OA=1
}} Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.

{{PMID|20550665|OA=1
}} Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.

{{PMID|21278902|OA=1
}} Genetic risk profiling for prediction of type 2 diabetes.

{{PMID|21625859}} Association between type 2 diabetes and CDKN2A/B: a meta-analysis study.

{{PMID|22377712}} Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs564398
|overall_frequency_n=1283
|overall_frequency_d=4586
|overall_frequency=0.279765
|n_genomes=19
|n_genomes_annotated=0
|n_haplomes=24
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23361049
|Title=Common genetic variants in the 9p21 region and their associations with multiple tumours
|OA=1
}}

{{PMID Auto
|PMID=23462794
|Title=Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}