{{Rsnum
|rsid=569108
|Gene=MS4A2
|Chromosome=11
|position=60095631
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.1194
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MS4A2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 9.7 | 90.3
| HCB | 4.5 | 30.6 | 64.9
| JPT | 0.9 | 29.5 | 69.6
| YRI | 6.8 | 27.9 | 65.3
| ASW | 3.5 | 33.3 | 63.2
| CHB | 4.5 | 30.6 | 64.9
| CHD | 4.6 | 29.4 | 66.1
| GIH | 0.0 | 5.0 | 95.0
| LWK | 10.1 | 46.8 | 43.1
| MEX | 1.8 | 5.3 | 93.0
| MKK | 6.5 | 29.2 | 64.3
| TSI | 0.0 | 8.9 | 91.1
| HapMapRevision=28
}}
[[rs569108]], a SNP in the [[MS4A2]] gene, has been linked in a Japanese population to a predisposition to childhood [[asthma]], with an odds ratio of 3 [PMID 8842731, PMID 8968765]. The risk allele in dbSNP orientation is (C). [Note: no (C;C) homozygotes were observed in this population.]

{{omim
|id=147138
|rsnum=569108
|variant=0001
}}

{{ClinVar
|rsid=569108
|Reversed=1
|FwdREF=T
|FwdALT=C
|REF=A
|ALT=G
|RSPOS=59863104
|CHROM=11
|GMAF=0.119
|dbSNPBuildID=83
|SSR=0
|SAO=1
|VP=0x050168000000150517110101
|GENEINFO=MS4A2:2206
|GENE_NAME=MS4A2
|GENE_ID=2206
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000011.9:g.59863104A>G
|CLNORIGIN=1
|CLNSIG=255
|Tags=RV;PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.8806; 0.1194
|CLNACC=RCV000015930.1
|CLNDBN=Atopic asthma, susceptibility to
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=147138.0001
|COMMON=1
|Disease=Atopic asthma
}}

{{PMID|15726497|OA=1
}} Gene-environment interaction effects on the development of immune responses in the 1st year of life.

{{PMID|16519819|OA=1
}} Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

{{PMID|19131662|OA=1
}} A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

{{PMID|19330901|OA=1
}} Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

{{PMID|19559392|OA=1
}} A candidate gene association study of 77 polymorphisms in migraine.

{{GET Evidence
|gene=MS4A2
|aa_change=Glu237Gly
|aa_change_short=E237G
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs569108
|overall_frequency_n=800
|overall_frequency_d=10758
|overall_frequency=0.0743633
|n_genomes=15
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=0
|n_articles_annotated=0
|in_omim=Y
|pph2_score=0.983
|nblosum100=6
|autoscore=3
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}