{{Rsnum
|rsid=569207
|Gene=CHRNA5
|Chromosome=15
|position=78580777
|Orientation=plus
|GMAF=0.3618
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CHRNA5
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 3.5 | 33.6 | 62.8
| HCB | 20.4 | 57.7 | 21.9
| JPT | 26.8 | 54.5 | 18.8
| YRI | 11.6 | 40.8 | 47.6
| ASW | 12.5 | 41.1 | 46.4
| CHB | 20.4 | 57.7 | 21.9
| CHD | 21.1 | 54.1 | 24.8
| GIH | 25.7 | 42.6 | 31.7
| LWK | 8.3 | 52.3 | 39.4
| MEX | 31.0 | 46.6 | 22.4
| MKK | 8.3 | 42.3 | 49.4
| TSI | 5.9 | 37.3 | 56.9
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs569207
|Name_s=
|Gene_s=CHRNA5
|Feature=
|Evidence=PubMed ID:18618000
|Annotation=The T allele of this SNP is associated with protection from early onset nicotine addiction, i.e., daily smoking commencing at or before age 16. Haplotype C, which is defined by the T allele of this SNP and the A allele of rs578776, is similarly associated with protection from early onset nicotine dependence.
|Drugs=nicotine
|Drug Classes=
|Diseases=Tobacco Use Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA162168240
}}

{{PMID Auto
|PMID=18519524
|Title=Variants in nicotinic receptors and risk for nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=19029397
|Title=Nicotinic receptor gene variants influence susceptibility to heavy smoking.
|OA=1
}}

{{PMID Auto
|PMID=19436041
|Title=Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=19443489
|Title=Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
|OA=1
}}

{{PMID Auto
|PMID=20700436
|Title=Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.
|OA=1
}}

{{PMID Auto
|PMID=20808433
|Title=Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs569207
|overall_frequency_n=2635
|overall_frequency_d=10756
|overall_frequency=0.24498
|n_genomes=32
|n_genomes_annotated=0
|n_haplomes=40
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}