{{Rsnum
|rsid = 5742904
|Gene = APOB
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Chromosome=2
|position=21006288
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=APOB
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 0.0 | 100.0
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

[[rs5742904]], also known as R3527Q, is a SNP in the [[APOB]] apolipoprotein B gene.

The risk allele is T according to 23andMe, which tests for this SNP in regard to [[familial hypercholesterolemia]] type B. In SNPedia, where we use the orientation as defined by dbSNP, the risk allele is [[rs5742904]](A).

For a clinical case discussion of this SNP, see 'Clinical Case 2' within Box 1 of {{PMID|19602640|OA=1
}}.

{{omim
|desc=HYPERCHOLESTEROLEMIA DUE TO LIGAND-DEFECTIVE APOLIPOPROTEIN B100
|id=107730
|rsnum=5742904
|variant=0009
}}

{{ neighbor
| rsid = 17241062
| distance = 93
}}

{{ClinVar
|rsid=5742904
|Reversed=1
|FwdREF=G
|FwdALT=A
|REF=C
|ALT=T
|RSPOS=21229160
|CHROM=2
|dbSNPBuildID=114
|SSR=0
|SAO=1
|VP=0x050068000000040103110100
|GENEINFO=APOB:338
|GENE_NAME=APOB
|GENE_ID=338
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000002.11:g.21229160C>T
|CLNORIGIN=1
|CLNSIG=5
|Tags=RV;PM;PMC;VLD;GNO;OTHERKG;PH3;LSD;OM
|CLNACC=RCV000019479.26
|CLNDBN=Familial hypercholesterolemia
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=107730.0009
|Disease=Familial hypercholesterolemia
|CLNDSDB=MedGen:OMIM:OMIM:SNOMED_CT:SNOMED_CT
|CLNDSDBID=C0020445:143890:144400:397915002:398036000
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

[[Familial Hypercholesterolemia Type B]]

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}