{{Rsnum
|rsid=5742909
|Gene=CTLA4
|Chromosome=2
|position=203867624
|Orientation=plus
|GMAF=0.07346
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CTLA4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 84.1 | 15.9 | 0.0
| HCB | 76.6 | 22.6 | 0.7
| JPT | 83.2 | 15.0 | 1.8
| YRI | 100.0 | 0.0 | 0.0
| ASW | 96.5 | 3.5 | 0.0
| CHB | 76.6 | 22.6 | 0.7
| CHD | 84.4 | 12.8 | 2.8
| GIH | 93.1 | 6.9 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 77.6 | 22.4 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 88.2 | 10.8 | 1.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=19619703
|Title=Association of genetic variants with the metabolic syndrome in 20,806 white women: The women's health genome study
|OA=1
}}

{{PMID Auto
|PMID=21040781
|Title=CTLA-4 confers a risk of recurrent schizophrenia, major depressive disorder and bipolar disorder in the Chinese Han population
}}

{{PMID Auto
|PMID=21513760
|Title=Association of CTLA4 gene polymorphisms with lymphatic filariasis in an East Malaysian population
}}

{{PMID Auto
|PMID=15452244
|Title=Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.
|OA=1
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=17683561
|Title=The TCF7L2 locus and type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=17697348
|Title=Technology to accelerate pangenomic scanning for unknown point mutations in exonic sequences: cycling temperature capillary electrophoresis (CTCE).
|OA=1
}}

{{PMID Auto
|PMID=17825114
|Title=Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population.
|OA=1
}}

{{PMID Auto
|PMID=18528295
|Title=Influence of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) common polymorphisms on outcome in treatment of melanoma patients with CTLA-4 blockade.
|OA=1
}}

{{PMID Auto
|PMID=18556337
|Title=Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).
|OA=1
}}

{{PMID Auto
|PMID=18576317
|Title=Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=18773895
|Title=The genetic basis of primary biliary cirrhosis: premises, not promises.
|OA=1
}}

{{PMID Auto
|PMID=18778710
|Title=Primary biliary cirrhosis is associated with a genetic variant in the 3' flanking region of the CTLA4 gene.
|OA=1
}}

{{PMID Auto
|PMID=19014504
|Title=Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19180256
|Title=Genotype analysis of polymorphisms in autoimmune susceptibility genes, CTLA-4 and PTPN22, in an acute anterior uveitis cohort.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19500380
|Title=LD2SNPing: linkage disequilibrium plotter and RFLP enzyme mining for tag SNPs.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=19622768
|Title=CTLA4 variants, UV-induced tolerance, and risk of non-melanoma skin cancer.
|OA=1
}}

{{PMID Auto
|PMID=19672595
|Title=Polymorphisms in the CD28/CTLA4/ICOS genes: role in malignant melanoma susceptibility and prognosis?
|OA=1
}}

{{PMID Auto
|PMID=19735686
|Title=CTLA-4 promoter polymorphisms are associated with latent autoimmune diabetes in adults.
}}

{{PMID Auto
|PMID=19740340
|Title=The CTLA-4 gene polymorphisms are associated with CTLA-4 protein expression levels in multiple sclerosis patients and with susceptibility to disease.
|OA=1
}}

{{PMID Auto
|PMID=19956097
|Title=Remapping the type I diabetes association of the CTLA4 locus.
|OA=1
}}

{{PMID Auto
|PMID=19956101
|Title=Overview of the Rapid Response data.
|OA=1
}}

{{PMID Auto
|PMID=20537165
|Title=The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=20557968
|Title=Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients.
}}

{{PMID Auto
|PMID=20610662
|Title=Association of single nucleotide polymorphisms in cytotoxic T-lymphocyte antigen 4 and susceptibility to autoimmune type 1 diabetes in Tunisians.
|OA=1
}}

{{PMID Auto
|PMID=20732370
|Title=CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease.
}}

{{PMID Auto
|PMID=21644231
|Title=[Single nucleotide polymorphisms of CTLA4 gene and their association with human cervical cancer].
}}

{{PMID Auto
|PMID=21669243
|Title=CTLA-4, CD28, and ICOS gene polymorphism associations with non-small-cell lung cancer.
}}

{{PMID Auto
|PMID=22414241
|Title=Cytotoxic T-lymphocyte associated antigen-4 gene polymorphisms and primary biliary cirrhosis: A systematic review.
}}

{{PMID Auto
|PMID=22418270
|Title=Polymorphisms in cytotoxic T lymphocyte associated antigen-4 influence the rate of acute rejection after renal transplantation in 167 Chinese recipients.
}}

{{PMID Auto
|PMID=23432218
|Title=Association between cytotoxic T-lymphocyte antigen 4 gene polymorphisms and primary biliary cirrhosis in Chinese population: data from a multicenter study
}}

{{PMID Auto
|PMID=23480667
|Title=Cytotoxic T-Lymphocyte Antigen-4 Genetic Variants and Risk of Ewing's Sarcoma
}}

{{PMID Auto
|PMID=23597029
|Title=The associations between the polymorphisms in the CTLA-4 gene and the risk of Graves' disease in the Chinese population
|OA=1
}}

{{PMID Auto
|PMID=23661460
|Title=CTLA-4 and CD86 genetic variants and haplotypes in patients with rheumatoid arthritis in southeastern China
}}

{{PMID Auto
|PMID=23703660
|Title=The -319C/+49G/CT60G Haplotype of CTLA-4 Gene Confers Susceptibility to Rheumatoid Arthritis in Mexican Population
}}

{{PMID Auto
|PMID=23830732
|Title=CTLA-4 gene polymorphism at position +49 A&gt;G in exon 1: a risk factor for cervical cancer in Indian women
}}

{{PMID Auto
|PMID=24270470
|Title=Influence of cytotoxic T lymphocyte-associated antigen 4 polymorphisms on the outcomes of hepatitis B virus infection
}}

{{PMID Auto
|PMID=24298899
|Title=Investigation of CTLA-4 and CD86 gene polymorphisms in a group of Iranian patients with brucellosis infection
}}

{{PMID Auto
|PMID=24313821
|Title=Association of CTLA-4 Gene Polymorphism with End-Stage Renal Disease and Renal Allograft Outcome
}}

{{PMID Auto
|PMID=24385694
|Title=Effect of cytotoxic T-lymphocyte antigen-4, TNF-alpha polymorphisms on osteosarcoma: evidences from a meta-analysis
|OA=1
}}

{{PMID Auto
|PMID=22905924
|Title=Cytotoxic T-lymphocyte antigen-4 polymorphisms and susceptibility to Ewing's sarcoma.
}}

{{PMID Auto
|PMID=22928528
|Title=Expression of genes involved in susceptibility to multifactorial autoimmune diseases: estimating genotype effects.
}}

{{PMID Auto
|PMID=23010350
|Title=Lack of association between CTLA-4 +49A/G and -318C/T polymorphisms and Behcet's disease risk: a meta-analysis.
}}

{{PMID Auto
|PMID=23133602
|Title=Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.
|OA=1
}}

{{PMID Auto
|PMID=23261408
|Title=-1722T/C polymorphism (rs733618) of CTLA-4 significantly associated with systemic lupus erythematosus (SLE): a comprehensive meta-analysis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}