{{Rsnum
|rsid=5743305
|Gene=TLR3
|Chromosome=4
|position=186068179
|Orientation=plus
|GMAF=0.3228
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=TLR3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 7.1 | 50.4 | 42.5
| HCB | 5.1 | 39.4 | 55.5
| JPT | 1.8 | 31.9 | 66.4
| YRI | 4.8 | 40.8 | 54.4
| ASW | 10.5 | 36.8 | 52.6
| CHB | 5.1 | 39.4 | 55.5
| CHD | 9.3 | 36.1 | 54.6
| GIH | 14.0 | 47.0 | 39.0
| LWK | 12.7 | 36.4 | 50.9
| MEX | 13.8 | 43.1 | 43.1
| MKK | 4.5 | 43.6 | 51.9
| TSI | 19.6 | 55.9 | 24.5
| HapMapRevision=28
}}{{PMID Auto
|PMID=19475618
|Title=TLR3 gene polymorphisms and liver disease manifestations in chronic hepatitis C
}}

{{PharmGKB
|RSID=rs5743305
|Name_s=
|Gene_s=TLR3
|Feature=
|Evidence=PubMed ID:18325643
|Annotation=Heterozygots for this variant -926 bp in promoter region of the TLR3 gene were associated with low antibody and lymphoproliferative responses (p <or= 0.02) to measles vaccination.
|Drugs=
|Drug Classes=MEASLES VACCINES
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA164925713
}}

{{PMID Auto
|PMID=19902255
|Title=Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes
|OA=1
}}

{{PMID|18598732|OA=1
}} Vaccine immunogenetics: bedside to bench to population.

{{PMID|18847302|OA=1
}} Personalized vaccines: the emerging field of vaccinomics.

{{PMID|19505919|OA=1
}} Toll-like receptor signaling pathway variants and prostate cancer mortality.

{{PMID|21872627}} Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs5743305
|overall_frequency_n=48
|overall_frequency_d=126
|overall_frequency=0.380952
|n_genomes=30
|n_genomes_annotated=0
|n_haplomes=37
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}