{{Rsnum
|rsid=5743618
|Gene=TLR1
|Chromosome=4
|position=38797027
|Orientation=minus
|GMAF=0.331
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=TLR1
}}{{omim
|id=601194
|desc=TOLL-LIKE RECEPTOR 1; TLR1
|rsnum=5743618
}}

{{PharmGKB
|RSID=rs5743618
|Name_s=TLR1: I602S
|Gene_s=TLR1
|Feature=
|Evidence=PubMed ID:18662133
|Annotation=The genotype distributions for the I602S variant in the TLR-1 gene differed significantly between patients with mild malaria and persons with asymptomatic infection. The 602S allele was associated with an odds ratio (OR) of 2.2 (P= .003) for malaria among patients with mild malaria.
|Drugs=
|Drug Classes=
|Diseases=Malaria
|Curation Level=Curated
|PharmGKB Accession ID=PA164925710
}}

{{omim
|id=601194
|rsnum=5743618
|variant=0001
}}

{{PMID Auto
|PMID=22238472
|Title=Variants in toll-like receptor 1 and 4 genes are associated with Chlamydia trachomatis among women with pelvic inflammatory disease
|OA=1
}}

{{ClinVar
|rsid=5743618
|Reversed=1
|FwdREF=G
|FwdALT=T
|REF=C
|ALT=A
|RSPOS=38798648
|CHROM=4
|dbSNPBuildID=114
|SSR=0
|SAO=1
|VP=0x050168000000170116110100
|GENEINFO=TLR1:7096
|GENE_NAME=TLR1
|GENE_ID=7096
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000004.11:g.38798648C>A
|CLNORIGIN=1
|CLNSIG=255
|Tags=RV;PM;PMC;SLO;VLD;G5A;G5;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.331; 0.669
|CLNACC=RCV000008865.3
|CLNDBN=Leprosy, protection against
|CLNDSDB=MedGen
|CLNDSDBID=C2750734
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=601194.0001
|COMMON=1
|Disease=Leprosy
}}

{{PMID Auto
|PMID=18396467
|Title=Genetic variation and haplotype structures of innate immunity genes in eastern India.
|OA=1
}}

{{PMID Auto
|PMID=18635889
|Title=Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis.
|OA=1
}}

{{PMID Auto
|PMID=19134200
|Title=No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19543401
|Title=Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.
|OA=1
}}

{{PMID Auto
|PMID=20016852
|Title=Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women.
|OA=1
}}

{{PMID Auto
|PMID=20478407
|Title=The toll-like receptor 1 variant S248N influences placental malaria.
}}

{{PMID Auto
|PMID=20617178
|Title=Leprosy and the adaptation of human toll-like receptor 1.
|OA=1
}}

{{PMID Auto
|PMID=21872627
|Title=Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.
}}

{{GET Evidence
|gene=TLR1
|aa_change=Ser602Ile
|aa_change_short=S602I
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs5743618
|overall_frequency_n=5219
|overall_frequency_d=10756
|overall_frequency=0.485218
|n_genomes=46
|n_genomes_annotated=0
|n_haplomes=78
|n_articles=1
|n_articles_annotated=1
|qualityscore_in_silico=2
|qualitycomment_in_silico=Y
|in_pharmgkb=Y
|nblosum100=5
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23255565
|Title=Racial variation in toll-like receptor variants among women with pelvic inflammatory disease.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | HumanOmni1Quad}}