{{Rsnum
|rsid=5743708
|Gene=TLR2
|Chromosome=4
|position=153705165
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.01194
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TLR2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 9.5 | 90.5
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
This SNP affects the risk of developing [[tuberculosis]]. [http://www.erj.ersjournals.com/cgi/content/abstract/23/2/219]

The AA genotype was found to be more significantly associated with [[tuberculosis]]. Allele frequencies for guanine (G) and A were found to be 0.95 and 0.05 in the control group and 0.86 and 0.14 in the TB patient group, respectively. The risk of developing [tuberculosis] was increased 6.04- and 1.60-fold for carriers of the AA and GA genotypes, respectively.

The variant of [[rs5743708]] known as Arg753Gln or R753Q appears to protect against [[Lyme disease]]. {{PMID|16081826}}

{{PMID|17667860}} Linked to [[preterm birth]] [[rs4696480]] (T-16934A and Arg753Gln) and [[rs5743708]]) (Thr399Ile) earlier birth for infants carrying (-16934TA/AA and 753ArgGln/GlnGln)

{{PMID Auto
|PMID=20595247
|Title=Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients
}}

{{PMID|16608528|OA=1
}} Genetic polymorphisms and susceptibility to lung disease.

{{PMID|16846490|OA=1
}} Lemierre's syndrome and genetic polymorphisms: a case report.

{{PMID|17565608|OA=1
}} Linkage between Toll-like receptor (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis.

{{PMID|18396467|OA=1
}} Genetic variation and haplotype structures of innate immunity genes in eastern India.

{{PMID|18975326}} Toll-like receptor 2 variants are associated with acute reactive arthritis.

{{PMID|19029192|OA=1
}} A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma.

{{PMID|19134200|OA=1
}} No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis.

{{PMID|19543401|OA=1
}} Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.

{{PMID|20016852|OA=1
}} Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women.

{{PMID|20196868|OA=1
}} Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.

{{PMID|20463618|OA=1
}} Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

{{PMID|20646321|OA=1
}} Toll-like receptor (TLR) and nucleosome-binding oligomerization domain (NOD) gene polymorphisms and endometrial cancer risk.

{{PMID|20818961}} Inflammatory mediators gene polymorphisms in preeclampsia.

{{PMID|21356257}} Toll-like receptor (TLR) 2 promoter and intron 2 polymorphisms are associated with increased risk for spontaneous bacterial peritonitis in liver cirrhosis.

{{PMID|21500195}} The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C.

{{PMID|22019578}} Further evidence for the relevance of TLR2 gene variants in spontaneous bacterial peritonitis.

{{PMID Auto
|PMID=22494793
|Title=Innate immunity gene single nucleotide polymorphisms and otitis media
}}

{{PMID Auto
|PMID=23151015
|Title=Toll-like receptor 3 gene polymorphisms and severity of pandemic A/H1N1/2009 influenza in otherwise healthy children
|OA=1
}}

{{PMID Auto
|PMID=23289617
|Title=Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.
}}

{{PMID Auto
|PMID=23417289
|Title=Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection.
}}

{{ClinVar
|ALT=A
|CAF=0.9881; 0.01194
|CHROM=4
|CLNACC=RCV000033853.2
|CLNALLE=1
|CLNDBN=Mycobacterium tuberculosis, susceptibility to
|CLNDSDB=MedGen:OMIM:Orphanet
|CLNDSDBID=C1834752:607948:3389
|CLNHGVS=NC_000004.11:g.154626317G>A
|CLNSIG=255
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=603028.0003
|COMMON=1
|Disease=Mycobacterium tuberculosis
|FwdALT=A
|FwdREF=G
|GENEINFO=TLR2:7097
|GENE_ID=7097
|GENE_NAME=TLR2
|REF=G
|RSPOS=154626317
|Reversed=0
|SAO=0
|SSR=0
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|VC=SNV
|VP=0x050168000000150517110101
|WGT=0
|dbSNPBuildID=114
|rsid=5743708
}}

{{PMID Auto
|PMID=25213166
|Title=An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}