{{Rsnum
|rsid=5743810
|Gene=TLR6
|Chromosome=4
|position=38828729
|Orientation=minus
|GMAF=0.1873
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TLR6
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 31.0 | 46.0 | 23.0
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 84.2 | 15.8 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 99.1 | 0.9 | 0.0
| GIH | 95.0 | 5.0 | 0.0
| LWK | 96.4 | 3.6 | 0.0
| MEX | 67.2 | 29.3 | 3.4
| MKK | 81.4 | 17.9 | 0.6
| TSI | 46.1 | 40.2 | 13.7
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs5743810
|Name_s=TLR6: S249P
|Gene_s=TLR6
|Feature=
|Evidence=PubMed ID:18662133
|Annotation=This study suggests that the TLR6 249S allele may be a risk factor for malaria.
|Drugs=
|Drug Classes=
|Diseases=Malaria
|Curation Level=Curated
|PharmGKB Accession ID=PA164925711
}}

{{PMID Auto
|PMID=20595247
|Title=Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients
}}

{{PMID Auto
|PMID=19134200
|Title=No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19307593
|Title=Signals of recent positive selection in a worldwide sample of human populations.
|OA=1
}}

{{PMID Auto
|PMID=19505919
|Title=Toll-like receptor signaling pathway variants and prostate cancer mortality.
|OA=1
}}

{{PMID Auto
|PMID=19543401
|Title=Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.
|OA=1
}}

{{PMID Auto
|PMID=19567509
|Title=Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.
|OA=1
}}

{{PMID Auto
|PMID=20200442
|Title=Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.
|OA=1
}}

{{GET Evidence
|gene=TLR6
|aa_change=Ser249Pro
|aa_change_short=S249P
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs5743810
|overall_frequency_n=7479
|overall_frequency_d=10758
|overall_frequency=0.695204
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=95
|n_articles=2
|n_articles_annotated=2
|in_pharmgkb=Y
|nblosum100=3
|autoscore=1
|webscore=N
|summary_short=same as "rs5743810" , 
}}

{{PMID Auto
|PMID=23255565
|Title=Racial variation in toll-like receptor variants among women with pelvic inflammatory disease.
|OA=1
}}

{{PMID Auto
|PMID=25213166
|Title=An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}