{{Rsnum
|rsid=5743815
|Gene=TLR6
|Chromosome=4
|position=38828194
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.01561
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TLR6
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 2.7 | 97.3
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 3.5 | 96.5
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 2.0 | 98.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 1.7 | 10.3 | 87.9
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 1.0 | 99.0
| HapMapRevision=28
}}

[[rs5743815]], a SNP in the [[TLR6]] gene also known as V427A, is associated with risk for developing [[Non-Hodgkin Lymphoma]] based on a study of 458 patients. The odds ratio is 5.20 (CI: 1.77-15.3, p<0.01). {{PMID|17827388|OA=1
}}

{{PMID Auto
|PMID=19505919
|Title=Toll-like receptor signaling pathway variants and prostate cancer mortality.
|OA=1
}}

{{PMID Auto
|PMID=19543401
|Title=Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.
|OA=1
}}

{{PMID Auto
|PMID=19567509
|Title=Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.
|OA=1
}}

{{PMID Auto
|PMID=20200442
|Title=Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.
|OA=1
}}

{{PMID Auto
|PMID=21872627
|Title=Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.
}}

{{GET Evidence
|gene=TLR6
|aa_change=Val427Ala
|aa_change_short=V427A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs5743815
|overall_frequency_n=119
|overall_frequency_d=10758
|overall_frequency=0.0110615
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=3
|n_articles=0
|n_articles_annotated=0
|nblosum100=2
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}