{{Rsnum
|rsid=5751876
|Gene=ADORA2A
|Chromosome=22
|position=24441333
|Orientation=plus
|ReferenceAllele=T
|GMAF=0.4807
|Gene_s=ADORA2A,C22orf45
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}Variation at this SNP, [[rs5751876]], also referred to as 1976C>T or 1976T>C, appears to influence how an individual responds to moderate levels (150mg) of [[caffeine]].

T/T carriers displaying significantly increased subjective levels of anxiety after consumption. {{PMID|12825092}} {{PMID|18305461|OA=1
}}

However [http://www.pharmgkb.org/rsid/rs5751876?tabType=tabGenetics a PharmGKB variant annotation] suggests it is (C;C) genotypes who are more sensitive to caffeine. 

[[rs5751876]] is not associated with how much [[coffee]] one drinks, though, nor with risk for Parkinson's disease, based on a study of 1,200 subjects.{{PMID|18759349}}

{{PMID Auto
|PMID=19902562
|Title=Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians
}}

{{PMID Auto
|PMID=20334879
|Title=Adenosine A(2A) receptor gene: Evidence for association of risk variants with panic disorder and anxious personality
}}
"[[rs2298383]] shows functional potential based on in silico analyses and might therefore represent the true underlying causal variant"

{{PMID Auto
|PMID=21658325
|Title=Adenosine A2A receptor polymorphisms in Korean patients with systemic sclerosis
}}

{{PMID Auto
|PMID=22012471
|Title=ADORA2A Gene Variation, Caffeine, and Emotional Processing: A Multi-level Interaction on Startle Reflex
|OA=1
}}

{{PMID Auto
|PMID=22745815
|Title=Affect-Modulated Startle: Interactive Influence of Catechol-O-Methyltransferase Val158Met Genotype and Childhood Trauma
|OA=1
}}

{{PMID Auto
|PMID=19565319
|Title=Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder.
}}

{{PMID Auto
|PMID=19591938
|Title=A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease.
}}

{{PMID Auto
|PMID=20386734
|Title=Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis.
|OA=1
}}

{{PMID Auto
|PMID=20396431
|Title=Genotyping sleep disorders patients.
|OA=1
}}

{{PMID Auto
|PMID=20520601
|Title=Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption.
|OA=1
}}

{{PMID Auto
|PMID=22336631
|Title=Caffeine increases tear volume depending on polymorphisms within the adenosine A2a receptor gene and cytochrome P450 1A2.
}}

{{PMID Auto
|PMID=23535492
|Title=ADORA2A polymorphism predisposes children to encephalopathy with febrile status epilepticus
|OA=1
}}

{{PMID Auto
|PMID=23018769
|Title=A survey of putative anxiety-associated genes in panic disorder patients with and without bladder symptoms
}}

{{PMID Auto
|PMID=22940476
|Title=Effects of ADORA2A gene variation and caffeine on prepulse inhibition: a multi-level risk model of anxiety.
}}

{{PMID Auto
|PMID=23332182
|Title=A study of the possible association between adenosine A2A receptor gene polymorphisms and attention-deficit hyperactivity disorder traits.
}}

{{PMID Auto
|PMID=24943643
|Title=Association of Adenosine Receptor Gene Polymorphisms and in vivo Adenosine A1 Receptor Binding in the Human Brain
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}