{{Rsnum
|rsid=5770917
|Gene=CHKB
|Chromosome=22
|position=50578924
|Orientation=plus
|GMAF=0.1157
|Gene_s=CHKB,CPT1B
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 9.8 | 90.2
| HCB | 8.8 | 28.7 | 62.5
| JPT | 2.7 | 38.1 | 59.3
| YRI | 0.0 | 7.2 | 92.8
| ASW | 0.0 | 7.0 | 93.0
| CHB | 8.8 | 28.7 | 62.5
| CHD | 6.4 | 35.8 | 57.8
| GIH | 2.0 | 35.0 | 63.0
| LWK | 0.0 | 9.1 | 90.9
| MEX | 6.9 | 34.5 | 58.6
| MKK | 0.0 | 3.2 | 96.8
| TSI | 0.0 | 6.9 | 93.1
| HapMapRevision=28
}}[[rs5770917]], a SNP located between the CPT1B and CHKB genes, was associated with [[narcolepsy]] in study of 222 Japanese individuals with narcolepsy and 389 Japanese controls, with replication of top hits in 159 Japanese individuals with narcolepsy and 190 Japanese controls, followed by the testing of 424 Koreans, 785 individuals of European descent and 184 African Americans. The risk allele [[rs5770917]](C) had an odds ratio of 1.79 (p = 4.4 x 10e-7) in Japanese subjects and an odds ratio of 1.40 (p = 0.02) in other ancestry groups.{{doi|10.1038/ng.231}}

Note that [[rs5770917]] is in tight linkage (r2 > 0.93) with several nearby SNPs: [[rs2269382]] and [[rs2269381]].{{doi|10.1038/ng.231}}

[[HLA-DQB1*0602]] and relevance to [[Narcolepsy]] related to vaccination

{{GWAS Summary
|SNP=rs5770917
|PubMedID=18820697
|Condition=Narcolepsy
|Gene=CPT1B
|Risk Allele=C
|pValue=6.00E-008
|OR=1.63
|95CI=1.37-1.95
}}

{{PMID Auto
|PMID=19404393
|Title=Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia)
|OA=1
}}

{{omim
|desc=NARCOLEPSY 4; NRCLP4
|id=612417
|rsnum=5770917
}}

{{PharmGKB
|RSID=rs5770917
|Name_s=
|Gene_s=CPT1B, CHKB
|Feature=
|Evidence=PubMed ID:18820697; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Variant between CPT1B and CHKB associated with susceptibility to narcolepsy (Initial Sample Size: 222 Japanese cases, 389 Japanese controls; Replication Sample Size: 748 cases, 994 controls; Risk Allele: rs5770917-C). This variant is associated with Narcolepsy.
|Drugs=
|Drug Classes=
|Diseases=Narcolepsy
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356586
}}

{{PMID Auto
|PMID=19412176
|Title=Narcolepsy is strongly associated with the T-cell receptor alpha locus.
|OA=1
}}

{{PMID Auto
|PMID=21358852
|Title=Abnormally low serum acylcarnitine levels in narcolepsy patients.
|OA=1
}}

{{PMID Auto
|PMID=22177342
|Title=TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs5770917
|overall_frequency_n=8
|overall_frequency_d=120
|overall_frequency=0.0666667
|n_genomes=7
|n_genomes_annotated=0
|n_haplomes=7
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}