{{Rsnum
|rsid=5800
|Gene=EDN2
|Chromosome=1
|position=41479019
|Orientation=minus
|GMAF=0.1469
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=EDN2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 22.0 | 78.0
| HCB | 0.0 | 7.0 | 93.0
| JPT | 0.9 | 0.0 | 99.1
| YRI | 8.5 | 25.4 | 66.1
| ASW | 3.6 | 0.0 | 96.4
| CHB | 0.0 | 7.0 | 93.0
| CHD | 0.9 | 0.0 | 99.1
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 3.0 | 1.0 | 96.0
| HapMapRevision=28
}}[[rs5800]], also known as A985G, is a SNP in the endothelin-2 [[EDN2]] gene.

In a study of 110 Japanese patients being treated for hypertrophic cardiomyopathy (HCM), the [[rs5800]](A) allele frequency was more than double in those who developed [[atrial fibrillation]] (AF) than among those who did not. This was statistically significant (p=0.014 by chi-square analysis, p=0.018 in an adjusted multivariate model).{{PMID|18037749}}

Note that the [[rs5800]](A) allele is not associated with increased risk for cardiomyopathy; in fact, it may even be somewhat protective. It is associated with atrial fibrillation only in patients with hypertrophic cardiotrophy.{{PMID|18037749}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}