{{Rsnum
|rsid=5908
|Gene=HMGCR
|Chromosome=5
|position=75356374
|Orientation=plus
|GMAF=0.006887
|Gene_s=HMGCR
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 95.6 | 4.4 | 0.0
| HCB | 97.8 | 2.2 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 97.8 | 2.2 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 99.0 | 1.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 98.3 | 1.7 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 99.0 | 1.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=22050757
|Title=Functional non-synonymous polymorphisms prediction methods: current approaches and future developments
}}

{{PMID Auto
|PMID=18802019
|Title=Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.
|OA=1
}}

{{PMID Auto
|PMID=19554360
|Title=The HMG-CoA reductase gene and lipid and lipoprotein levels: the multi-ethnic study of atherosclerosis.
|OA=1
}}

{{PMID Auto
|PMID=20578904
|Title=Common variants of HMGCR, CETP, APOAI, ABCB1, CYP3A4, and CYP7A1 genes as predictors of lipid-lowering response to atorvastatin therapy.
}}

{{GET Evidence
|gene=HMGCR
|aa_change=Ile638Val
|aa_change_short=I638V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs5908
|overall_frequency_n=139
|overall_frequency_d=10758
|overall_frequency=0.0129206
|n_genomes=2
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|nblosum100=-4
|autoscore=2
|n_web_uneval=10
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}