{{Rsnum
|rsid=5963409
|Gene=OTC
|Chromosome=X
|position=38351716
|Orientation=plus
|GMAF=0.3071
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=OTC
}}[[rs5963409]] is a SNP in the ornithine carbamoyltransferase [[OTC]] gene; this SNP is also known as the -389 G/A SNP.

Previous association studies were extended to a population of 2113 [[Alzheimer's disease]] cases and 1580 controls from northern France, western France, the United Kingdom and Italy. The [[rs5963409]](A) minor allele was weakly but significantly associated with an increased risk of developing [[Alzheimer's disease]] (odds ratio 1.19, p = 0.004). This association was independent of age and [[ApoE]] status.{{PMID|18983895}}
{{PMID Auto
|PMID=19574962
|Title=Association of Ornithine Transcarbamylase Gene Polymorphisms With Hypertension and Coronary Artery Vasomotion
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}