{{Rsnum
|rsid=5984894
|Gene=PCDH11X
|Chromosome=X
|position=92138738
|Orientation=plus
|GMAF=0.4051
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PCDH11X
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 39.3 | 23.2 | 37.5
| HCB | 78.7 | 14.0 | 7.4
| JPT | 79.6 | 10.6 | 9.7
| YRI | 12.0 | 14.8 | 73.2
| ASW | 14.0 | 26.3 | 59.6
| CHB | 78.7 | 14.0 | 7.4
| CHD | 86.0 | 7.5 | 6.5
| GIH | 58.0 | 15.0 | 27.0
| LWK | 23.1 | 25.9 | 50.9
| MEX | 69.0 | 19.0 | 12.1
| MKK | 25.7 | 19.7 | 54.6
| TSI | 40.2 | 27.5 | 32.4
| HapMapRevision=28
}}[[rs5984894]] is a SNP located within an intron of the protocadherin 11 [[PCDH11X]] gene, on the X chromosome.

A study of 2,391 patients with late-onset [[Alzheimer's disease]] reports that [[rs5984894]] is particularly associated with increased risk for the disease in females, as compared to males. In this study, the patients were Americans of European descent, and 62% were female. Odds ratios were 1.75 (CI: 1.42–2.16) for female homozygotes (p = 2 x 10e-7) and 1.26 (CI: 1.05–1.51) for female heterozygotes (p = 0.01) compared to [[rs5984894]](G;G) females.{{PMID|19136949|OA=1
}} 

For male [[rs5984894]](-;A) hemizygotes (p = 0.07, which may mean this is insignificant since it is above the traditional cut-off of 0.05) compared to male [[rs5984894]](-;G) noncarriers, the odds ratio was 1.18 (CI: 0.99–1.41).{{PMID|19136949|OA=1
}}

A more recent and independent - but also smaller - study found no association between late-onset Alzheimer disease and [[rs5984894]] in a dataset of 889 cases and 850 controls, indicating that "the PCDH11X association, if not a false positive, is not as strong or generalized as hypothesized earlier".{{PMID|20523261|OA=1
}}

{{omim
|desc=ALZHEIMER DISEASE 16; AD16
|id=300756
|rsnum=5984894
}}

{{PMID Auto
|PMID=20555150
|Title=Failure to Replicate an Association of rs5984894 SNP in the PCDH11X Gene in a Collection of 1,222 Alzheimer's Disease Affected Patients
}}
{{PMID Auto
|PMID=20707987
|Title=Lack of association between PCDH11X genetic variation and late-onset Alzheimer's disease in a Han Chinese population
}}

{{PMID|19734902|OA=1
}} Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.

{{PMID|20574532|OA=1
}} Intermediate phenotypes identify divergent pathways to Alzheimer's disease.

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}