{{Rsnum
|rsid=6006460
|Gene=PNPLA3
|Chromosome=22
|position=43946294
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=T
|GMAF=0.03168
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=PNPLA3
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 100.0 | 0.0 | 0.0
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 77.8 | 20.6 | 1.6
| ASW | 69.6 | 30.4 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 70.0 | 29.1 | 0.9
| MEX | 0.0 | 0.0 | 0.0
| MKK | 85.3 | 14.7 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[http://www.nature.com/ng/journal/v40/n12/abs/ng.257.html nature] [[rs6006460]](T) (S453I)  lower hepatic fat content; by an average of 18% compared to the common (G;G) genotypes, at least as measured in African-Americans sampled.

{{omim
|id=228100
|desc=FATTY METAMORPHOSIS OF VISCERA
|rsnum=6006460
}}

{{omim
|id=613282
|rsnum=6006460
}}

{{PMID Auto
|PMID=18820647
|Title=Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.
|OA=1
}}

{{GET Evidence
|gene=PNPLA3
|aa_change=Ser453Ile
|aa_change_short=S453I
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6006460
|overall_frequency_n=384
|overall_frequency_d=10758
|overall_frequency=0.0356944
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=3
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.017
|nblosum100=5
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}