{{Rsnum
|rsid=601338
|Gene=FUT2
|Chromosome=19
|position=48703417
|Orientation=plus
|ReferenceAllele=G
|GMAF=0.3242
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=FUT2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 30.4 | 45.5 | 24.1
| HCB | 0.0 | 2.9 | 97.1
| JPT | 0.0 | 1.8 | 98.2
| YRI | 27.4 | 54.1 | 18.5
| ASW | 30.4 | 46.4 | 23.2
| CHB | 0.0 | 2.9 | 97.1
| CHD | 0.0 | 0.0 | 0.0
| GIH | 4.0 | 37.0 | 59.0
| LWK | 22.0 | 45.0 | 33.0
| MEX | 8.6 | 56.9 | 34.5
| MKK | 15.6 | 45.5 | 39.0
| TSI | 23.5 | 48.0 | 28.4
| HapMapRevision=28
}}
[[rs601338]] is found on chromosome 19 in the alpha(1,2)-fucosyltransferase [[FUT2]] gene. The wild-type [[rs601338]](G) encodes the "secretor" (Se) allele, while [[rs601338]](A) encodes the "non-secretor" (se) allele.

A study of 115 Swedish adults concluded that [[rs601338]](A;A) homozygotes have genetic immunity to infection by the Norwalk norovirus, a major (and contagious) cause of acute gastroenteritis worldwide among adults. {{PMID|12692541}} {{PMID|16306606|OA=1
}} This illness is also known as "cruise ship gastroenteritis."

Being a non-secretor may have other consequences, such as greater susceptibility to infection by influenza viruses and by some types of bacteria. [[23andMe]] discusses these [https://www.23andme.com/health/Norovirus-Resistance/ topics].

In some non-Caucasian populations, a different SNP is responsible for non-secretor phenotypes. For example, although the Se allele is absent in Japanese, 15% are non-secretors based on being homozygous for the non-secretor "sej" allele of SNP [[rs1047781]]. {{PMID|8621666}}

http://blog.personalgenomes.org/2012/02/29/invulnerability-to-stomach-flu-is-my-secret-superpower/

http://evidence.personalgenomes.org/FUT2-W154X

{{ neighbor
| rsid = 492602
| distance = 257
}}

{{omim
|desc=VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1; B12QTL1
|id=612542
|rsnum=601338
}}

{{omim
|desc=FUCOSYLTRANSFERASE 2; FUT2
|id=182100
|rsnum=601338
}}
{{PMID Auto
|PMID=19744961
|Title=Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway
|OA=1
}}

{{PharmGKB
|RSID=rs601338
|Name_s=FUT2: W143X
|Gene_s=FUT2
|Feature=
|Evidence=PubMed ID:7876235
|Annotation=Results from in vitro expression assays indicate that this polymorphism, which creates the translation termination codon, inactivates this allele. Approximately 20% of randomly-selected individuals were found to be homozygous for this enzyme-inactivating nonsense allele, in correspondence to the frequency of the non-secretor phenotype in most human populations.
|Drugs=cyanocobalamin
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA162355649
}}

{{PMID Auto
|PMID=22521342
|Title=Extended Analysis of a Genome-Wide Association Study in Primary Sclerosing Cholangitis Detects Multiple Novel Risk Loci.
|OA=1
}}

{{ClinVar
|rsid=601338
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=49206674
|CHROM=19
|GMAF=0.3242
|dbSNPBuildID=83
|SSR=0
|SAO=1
|VP=0x050168000000150517110100
|GENEINFO=FUT2:2524
|GENE_NAME=FUT2
|GENE_ID=2524
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.49206674G>A
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=182100.0001
|CLNSIG=255
|CLNCUI=C2674252
|CLNDBN=SECRETOR/NONSECRETOR POLYMORPHISM; Norwalk virus infection, resistance to; Vitamin b12 plasma level quantitative trait locus 1
|Disease=SECRETOR/NONSECRETOR POLYMORPHISM; Norwalk virus infection; Vitamin b12 plasma level quantitative trait locus 1
|CLNACC=RCV000013808.2; RCV000013809.22; RCV000013810.2
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.6758; 0.3242
|CLNDSDB=MedGen; MedGen:OMIM
|CLNDSDBID=C1866980; C2674252:612542
|COMMON=1
}}

{{PMID|18604267|OA=1
}} Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.

{{PMID|18776911|OA=1
}} Common variants of FUT2 are associated with plasma vitamin B12 levels.

{{PMID|19169360|OA=1
}} Histo-blood group gene polymorphisms as potential genetic modifiers of infection and cystic fibrosis lung disease severity.

{{PMID|19379518|OA=1
}} Development of a fingerprinting panel using medically relevant polymorphisms.

{{PMID|19474294|OA=1
}} Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

{{PMID|20041166|OA=1
}} Common genetic variation and the control of HIV-1 in humans.

{{PMID|20565774|OA=1
}} Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

{{PMID|22025780|OA=1
}} FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection.

{{GET Evidence
|gene=FUT2
|aa_change=Trp154Stop
|aa_change_short=W154X
|impact=protective
|qualified_impact=Moderate clinical importance,  protective
|inheritance=recessive
|quality_scores=Array
|dbsnp_id=rs601338
|overall_frequency_n=5277
|overall_frequency_d=10758
|overall_frequency=0.490519
|n_genomes=55
|n_genomes_annotated=0
|n_haplomes=71
|n_articles=5
|n_articles_annotated=5
|qualityscore_in_silico=2
|qualitycomment_in_silico=Y
|qualityscore_in_vitro=2
|qualitycomment_in_vitro=Y
|qualityscore_case_control=4
|qualitycomment_case_control=Y
|qualityscore_severity=2
|qualitycomment_severity=Y
|qualityscore_treatability=3
|qualitycomment_treatability=Y
|in_pharmgkb=Y
|nblosum100=10
|autoscore=2
|webscore=N
|variant_evidence=1
|clinical_importance=2
|summary_short=This recessive protective variant confers resistance to norovirus (which causes stomach flu). 20% of Caucasians and Africans are homozygous for this variant and are "non-secretors": they do not express ABO blood type antigens in their saliva or mucosal surfaces. Most strains of norovirus bind to these antigens in the gut, and so this non-secretor status confers almost total resistantance to most types of norovirus. There are notable exceptions, some strains of norovirus bind a different target and are equally infectious for secretors and non-secretors.
}}

[[Norovirus Resistance]]

{{PMID Auto
|PMID=23402911
|Title=Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant
}}

{{PMID Auto
|PMID=23075394
|Title=Association study of FUT2 (rs601338) with celiac disease and inflammatory bowel disease in the Finnish population.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}