{{Rsnum
|rsid=602662
|Gene=FUT2
|Chromosome=19
|position=48703728
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.3375
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=FUT2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 34.5 | 46.9 | 18.6
| HCB | 0.0 | 2.2 | 97.8
| JPT | 0.0 | 0.0 | 100.0
| YRI | 27.2 | 53.7 | 19.0
| ASW | 31.6 | 45.6 | 22.8
| CHB | 0.0 | 2.2 | 97.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 4.0 | 37.6 | 58.4
| LWK | 21.8 | 45.5 | 32.7
| MEX | 10.3 | 55.2 | 34.5
| MKK | 16.7 | 46.2 | 37.2
| TSI | 25.5 | 48.0 | 26.5
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19303062
|Trait=Folate pathway vitamins
|Title=Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations
|RiskAllele=A
|Pval=3E-20
|OR=49.77
|ORtxt=[37.09-62.45] pg/ml increase
|OA=1
}}

{{omim
|desc=VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1; B12QTL1
|id=612542
|rsnum=602662
}}
{{PMID Auto
|PMID=19744961
|Title=Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway
|OA=1
}}

{{PharmGKB
|RSID=rs602662
|Name_s=
|Gene_s=FUT2
|Feature=
|Evidence=PubMed ID:19303062; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations. (Initial Sample Size: 2,934 individuals; Replication Sample Size: 686 individuals); (Region: 19q13.33; Reported Gene(s): FUT2; Risk Allele: rs602662-A); (p-value= 3E-20).This variant is associated with Folate pathway vitamins.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739923
}}

{{omim
|id=182100
|rsnum=602662
}}

{{PMID Auto
|PMID=18776911
|Title=Common variants of FUT2 are associated with plasma vitamin B12 levels.
|OA=1
}}

{{PMID Auto
|PMID=18997004
|Title=Widespread balancing selection and pathogen-driven selection at blood group antigen genes.
|OA=1
}}

{{PMID Auto
|PMID=20570966
|Title=Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=21115529
|Title=Genetics and genomics of human ageing.
|OA=1
}}

{{GET Evidence
|gene=FUT2
|aa_change=Gly258Ser
|aa_change_short=G258S
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs602662
|overall_frequency_n=5472
|overall_frequency_d=10758
|overall_frequency=0.508645
|n_genomes=38
|n_genomes_annotated=0
|n_haplomes=48
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=1
|qualitycomment_in_silico=Y
|in_gwas=Y
|in_pharmgkb=Y
|pph2_score=0.954
|nblosum100=2
|autoscore=3
|webscore=N
}}

{{PMID Auto
|PMID=22521342
|Title=Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci.
|OA=1
}}

{{PMID Auto
|PMID=23201895
|Title=Common variant in FUT2 gene is associated with levels of vitamin B(12) in Indian population.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}