{{Rsnum
|rsid=6028945
|Chromosome=20
|position=40192165
|Orientation=plus
|GMAF=0.1088
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 68.8 | 28.6 | 2.7
| HCB | 76.3 | 23.0 | 0.7
| JPT | 66.4 | 32.7 | 0.9
| YRI | 88.4 | 11.6 | 0.0
| ASW | 92.9 | 5.4 | 1.8
| CHB | 76.3 | 23.0 | 0.7
| CHD | 74.1 | 24.1 | 1.9
| GIH | 61.4 | 37.6 | 1.0
| LWK | 93.6 | 5.5 | 0.9
| MEX | 89.5 | 10.5 | 0.0
| MKK | 96.2 | 3.8 | 0.0
| TSI | 72.5 | 24.5 | 2.9
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=18615156
|Trait=Treatment response to TNF antagonists
|Title=Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in Rheumatoid Arthritis
|RiskAllele=T
|Pval=1.9999999999999999E-7
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PharmGKB
|RSID=rs6028945
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18615156
|Annotation=This variant is significantly associated with the efficacy of anti-TNF treatment in rheumatoid arthritis (Adjusted P-value: 0.0000002; OR: 11.2 (2.3, 108.1)). The study is a genome-wide association study using the Illumina HapMap300 SNP chip on 89 RA patients prospectively followed after beginning of anti-TNF therapy.
|Drugs=adalimumab; etanercept; infliximab
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA162928831
}}

{{PMID Auto
|PMID=20423481
|Title=Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6028945
|overall_frequency_n=10
|overall_frequency_d=128
|overall_frequency=0.078125
|n_genomes=7
|n_genomes_annotated=0
|n_haplomes=8
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
|n_web_uneval=10
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}