{{Rsnum
|rsid=6046
|Gene=F7
|Chromosome=13
|position=113118845
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.09412
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=F7
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 78.0 | 19.3 | 2.8
| HCB | 83.6 | 16.4 | 0.0
| JPT | 86.2 | 12.8 | 0.9
| YRI | 74.5 | 25.5 | 0.0
| ASW | 89.1 | 9.1 | 1.8
| CHB | 83.6 | 16.4 | 0.0
| CHD | 94.4 | 5.6 | 0.0
| GIH | 51.0 | 46.0 | 3.0
| LWK | 71.3 | 26.9 | 1.9
| MEX | 69.1 | 29.1 | 1.8
| MKK | 58.1 | 38.7 | 3.2
| TSI | 68.0 | 27.0 | 5.0
| HapMapRevision=28
}}
{{omim
|desc=MYOCARDIAL INFARCTION, DECREASED SUSCEPTIBILITY TO
|id=227500
|rsnum=6046
|variant=0014
}}

{{PMID Auto
|PMID=19404551
|Title=Association of genetic variants with myocardial infarction in Japanese individuals with chronic kidney disease
}}
{{PMID Auto
|PMID=19415820
|Title=The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study
|OA=1
}}

{{PMID Auto
|PMID=19336475
|Title=Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk
|OA=1
}}
{{PMID Auto
|PMID=20031567
|Title=An Evaluation of Candidate Genes of Inflammation and Thrombosis in Relation to the Risk of Venous Thromboembolism: The Women's Genome Health Study
|OA=1
}}

{{PMID Auto
|PMID=21291465
|Title=The association of genetic polymorphisms with cerebral palsy: a meta-analysis
}}

{{ClinVar
|rsid=6046
|Reversed=1
|FwdREF=C
|FwdALT=A,G,T
|REF=G
|ALT=A,C,T
|RSPOS=113773159
|CHROM=13
|GMAF=0.0943
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x050378000000150517110105
|GENEINFO=F7:2155
|GENE_NAME=F7
|GENE_ID=2155
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000013.10:g.113773159G>A
|CLNORIGIN=1
|CLNSIG=255
|Tags=RV;PM;TPA;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM;NOV
|CAF=0.9059; 0.09412; .
|CLNACC=RCV000012861.1
|CLNDBN=Myocardial infarction, decreased susceptibility to
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=613878.0014
|COMMON=1
|Disease=Myocardial infarction
}}

{{PMID Auto
|PMID=16846490
|Title=Lemierre's syndrome and genetic polymorphisms: a case report.
|OA=1
}}

{{PMID Auto
|PMID=17048007
|Title=Association of warfarin dose with genes involved in its action and metabolism.
|OA=1
}}

{{PMID Auto
|PMID=17903294
|Title=Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=18403734
|Title=Polymorphisms in platelet glycoprotein 1balpha and factor VII and risk of ischemic stroke: a meta-analysis.
}}

{{PMID Auto
|PMID=18513389
|Title=New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=20735728
|Title=Haplotype and genotype effects of the F7 gene on circulating factor VII, coagulation activation markers and incident coronary heart disease in UK men.
|OA=1
}}

{{PMID Auto
|PMID=21114618
|Title=Association of coagulation-related and inflammation-related genes and factor VIIc levels with stroke: the Cardiovascular Health Study.
|OA=1
}}

{{GET Evidence
|gene=F7
|aa_change=Arg413Gln
|aa_change_short=R413Q
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6046
|overall_frequency_n=10
|overall_frequency_d=124
|overall_frequency=0.0806452
|n_genomes=7
|n_genomes_annotated=0
|n_haplomes=7
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=0.112
|genetests_testable=Y
|nblosum100=0
|autoscore=2
|n_web_uneval=9
}}

{{PMID Auto
|PMID=22815813
|Title=Functional epistatic interaction between rs6046G&gt;A in F7 and rs5355C&gt;T in SELE modifies systolic blood pressure levels
|OA=1
}}

{{PMID Auto
|PMID=23298194
|Title=Epistatic study reveals two genetic interactions in blood pressure regulation
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}