{{Rsnum
|rsid=6050
|Gene=FGA
|Chromosome=4
|position=154586438
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.3292
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=FGA
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 58.9 | 34.8 | 6.2
| HCB | 24.1 | 51.1 | 24.8
| JPT | 27.4 | 52.2 | 20.4
| YRI | 29.9 | 53.1 | 17.0
| ASW | 33.3 | 56.1 | 10.5
| CHB | 24.1 | 51.1 | 24.8
| CHD | 23.1 | 52.8 | 24.1
| GIH | 57.0 | 36.0 | 7.0
| LWK | 48.6 | 38.5 | 12.8
| MEX | 52.6 | 45.6 | 1.8
| MKK | 48.7 | 45.4 | 5.9
| TSI | 55.9 | 38.2 | 5.9
| HapMapRevision=28
}}{{Venter SNP
|rsid=6050
|allele=C
|frequency=0.258
|uid=1103654590952
|type=heterozygous_SNP
|hugo=FGA
|ensembl gene=ENSG00000171560
|ensembl transcript=ENST00000302053
|sift=TOLERATED
|disease=Defects in FGA are a cause of hereditary renal amyloidosis (MIM:105200).
}}

{{omim
|id=134820
|rsnum=6050
|variant=0026
}}

{{PMID Auto GWAS
|PMID=21757653
|Trait=None
|Title=Association of {gamma}' Fibrinogen With Cardiovascular Disease.
|RiskAllele=C
|Pval=9E-90
|OR=0.2600
|ORtxt=[0.23-0.29] g/L decrease
|OA=1
}}

{{PMID Auto
|PMID=22386478
|Title=Fibrinogen polymorphisms associated with sporadic cerebral hemorrhage in a Chinese population
}}

{{PMID Auto
|PMID=22642105
|Title=[Polymorphic variants of genes encoding interleukin-6 and fibrinogen, the risk of ischemic stroke and fibrinogen levels]
}}

{{ClinVar
|rsid=6050
|Reversed=1
|FwdREF=A
|FwdALT=G
|REF=T
|ALT=C
|RSPOS=155507590
|CHROM=4
|GMAF=0.3297
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x05037800000017051f130101
|GENEINFO=FGA:2243
|GENE_NAME=FGA
|GENE_ID=2243
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000004.11:g.155507590T>C
|CLNORIGIN=1
|CLNSIG=255
|Tags=RV;PM;TPA;PMC;S3D;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;MTP;OM
|CAF=0.6708; 0.3292
|CLNACC=RCV000017882.1
|CLNDBN=Venous thromboembolism, susceptibility to
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=134820.0026
|COMMON=1
|Disease=Venous thromboembolism
}}

{{PMID Auto
|PMID=16846490
|Title=Lemierre's syndrome and genetic polymorphisms: a case report.
|OA=1
}}

{{PMID Auto
|PMID=19552680
|Title=Common hemostasis and inflammation gene variants and venous thrombosis in older adults from the Cardiovascular Health Study.
|OA=1
}}

{{PMID Auto
|PMID=20059469
|Title=Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study.
|OA=1
}}

{{PMID Auto
|PMID=20416077
|Title=Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
|OA=1
}}

{{PMID Auto
|PMID=22267327
|Title=Fibrinogen and factor XIII A-subunit genotypes interactively influence C-reactive protein levels during inflammation.
}}

{{PMID Auto
|PMID=22273812
|Title=Replication and characterisation of genetic variants in the fibrinogen gene cluster with plasma fibrinogen levels and haematological traits in the Third National Health and Nutrition Examination Survey.
|OA=1
}}

{{GET Evidence
|gene=FGA
|aa_change=Thr331Ala
|aa_change_short=T331A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6050
|overall_frequency_n=3111
|overall_frequency_d=10758
|overall_frequency=0.28918
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=32
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=0.306
|genetests_testable=Y
|nblosum100=1
|autoscore=2
|n_web_uneval=2
}}

{{PMID Auto
|PMID=24908450
|Title=A genetic association study of D-dimer levels with 50K SNPs from a candidate gene chip in four ethnic groups
}}

{{PMID Auto
|PMID=23944290
|Title=Association between two functional fibrinogen-related polymorphisms and ischemic stroke: a case-control study
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}