{{Rsnum
|rsid=60910145
|Gene=APOL1
|Chromosome=22
|position=36265988
|Orientation=plus
|GMAF=0.04959
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=APOL1
}}The derived allele of coding SNP [[rs60910145]] (p.I384M) defines, together with the derived allele of coding SNP [[rs73885319]] (p.S342G), the APOL1 G1 allele. This allele has been shown to associate with kidney disease while conferring protection against Trypanosoma brucei rhodesiense. {{doi|10.1126/science.1193032}}

{{omim
|id=603743
|desc=APOLIPOPROTEIN L-I; APOL1
|rsnum=60910145
}}
{{omim
|id=603743
|rsnum=60910145
|variant=0001
}}{{PMID Auto
|PMID=20635188
|Title=Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene.
|OA=1
}}{{GET Evidence
|gene=APOL1
|aa_change=Ile384Met
|aa_change_short=I384M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs60910145
|overall_frequency_n=808
|overall_frequency_d=10756
|overall_frequency=0.0751209
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=15
|n_articles=0
|n_articles_annotated=0
|nblosum100=-1
|autoscore=0
|webscore=N
}}{{ClinVar
|ALT=G
|CAF=0.9504; 0.04959
|CHROM=22
|CLNALLE=1
|CLNHGVS=NC_000022.10:g.36662034T>G
|CLNSIG=1
|COMMON=1
|FwdALT=G
|FwdREF=T
|GENEINFO=APOL1:8542
|GENE_ID=8542
|GENE_NAME=APOL1
|REF=T
|RSPOS=36662034
|Reversed=0
|SAO=0
|SSR=0
|Tags=PM;PMC;SLO;NSM;REF;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;LSD;OM
|VC=SNV
|VP=0x050168000a0117051e110100
|WGT=1
|dbSNPBuildID=129
|rsid=60910145
}}{{PMID Auto
|PMID=22956460
|Title=Genetic variation in APOL1 and MYH9 genes is associated with chronic kidney disease among Nigerians.
|OA=1
}}