{{Rsnum
|rsid=610604
|Gene=TNFAIP3
|Chromosome=6
|position=137878280
|Orientation=minus
|GMAF=0.3627
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=TNFAIP3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 32.7 | 49.6 | 17.7
| HCB | 78.1 | 20.4 | 1.5
| JPT | 87.6 | 12.4 | 0.0
| YRI | 8.8 | 40.8 | 50.3
| ASW | 15.8 | 43.9 | 40.4
| CHB | 78.1 | 20.4 | 1.5
| CHD | 73.4 | 26.6 | 0.0
| GIH | 48.5 | 39.6 | 11.9
| LWK | 6.4 | 40.9 | 52.7
| MEX | 32.8 | 53.4 | 13.8
| MKK | 16.7 | 51.3 | 32.1
| TSI | 49.0 | 40.2 | 10.8
| HapMapRevision=28
}}
[http://blog.23andme.com/2009/01/26/snpwatch-new-psoriasis-snps-found-for-both-europeans-and-asians/ 23andMe blog] [[psoriasis]] 
Europeans
*[[rs610604]](G) 	1.19x risk

{{PMID Auto GWAS
|PMID=19169254
|Trait=Psoriasis
|Title=Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
|RiskAllele=G
|Pval=9E-12
|OR=1.19
|ORtxt=None
|OA=1
}}

{{PharmGKB
|RSID=rs610604
|Name_s=
|Gene_s=TNFAIP3
|Feature=Intron
|Evidence=PubMed ID:19169254; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. (Initial Sample Size: 1,359 cases, 1,400 controls; Replication Sample Size: 5,048 cases, 5,041 controls); (Region: 6q23.3; Reported Gene(s): TNFAIP3; Risk Allele: rs610604-G); (p-value= 0.000000000009).This variant is associated with Psoriasis.
|Drugs=
|Drug Classes=
|Diseases=Psoriasis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740044
}}

{{PMID Auto GWAS
|PMID=20953190
|Trait=None
|Title=A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
|RiskAllele=
|Pval=7E-7
|OR=1.2200
|ORtxt=[1.13-1.32]
|OA=1
}}

{{PMID Auto
|PMID=21623003
|Title=Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis
|OA=1
}}

{{PMID Auto
|PMID=22113471
|Title=TNFAIP3 gene polymorphisms are associated with response to TNF blockade in psoriasis.
|OA=1
}}

{{PMID Auto
|PMID=17259397
|Title=Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes.
}}

{{PMID Auto
|PMID=19262574
|Title=Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis.
|OA=1
}}

{{PMID Auto
|PMID=21253569
|Title=Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs610604
|overall_frequency_n=77
|overall_frequency_d=128
|overall_frequency=0.601562
|n_genomes=46
|n_genomes_annotated=0
|n_haplomes=66
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23161053
|Title=TNFAIP3 gene polymorphisms confer risk for Behcet's disease in a Chinese Han population
}}

{{PMID Auto
|PMID=23521149
|Title=Pharmacogenetics of psoriasis: HLA-Cw6 but not LCE3B/3C deletion nor TNFAIP3 polymorphism predisposes to clinical response to interleukin 12/23 blocker ustekinumab.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}