{{Rsnum
|rsid=6123837
|Gene=GNAS
|Chromosome=20
|position=58890516
|Orientation=plus
|GMAF=0.3779
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=GNAS,LOC101927932
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 16.8 | 48.7 | 34.5
| HCB | 48.2 | 40.9 | 10.9
| JPT | 33.6 | 48.7 | 17.7
| YRI | 0.0 | 1.4 | 98.6
| ASW | 1.8 | 12.3 | 86.0
| CHB | 48.2 | 40.9 | 10.9
| CHD | 46.8 | 44.0 | 9.2
| GIH | 40.6 | 42.6 | 16.8
| LWK | 0.0 | 4.5 | 95.5
| MEX | 27.6 | 50.0 | 22.4
| MKK | 0.0 | 12.2 | 87.8
| TSI | 17.6 | 38.2 | 44.1
| HapMapRevision=28
}}[[rs6123837]] ( G(-1211)A ) is a SNP within [[GNAS]] (GNAS complex locus - encoding the Gs alpha subunit).

{{PMID|18192900}} among a group of 110 individuals participating in a randomized placebo-controlled weight loss trial (and under a low calorie diet)...
*those with GG genotypes lost significantly more weight compared to A allele carriers<br>
*[[sibutramine]] was effective only in A allele carriers for weight loss, however, carriers for two Gs showed the strongest increases in resting heart rate and systolic blood pressure

{{PMID Auto
|PMID=19593725
|Title=Association of maternally inherited GNAS alleles with African-American male birth weight.
|OA=1
}}

{{PMID Auto
|PMID=23065660
|Title=GNAS A-1121G variant is associated with improved diastolic dysfunction in response to exercise training in heart failure patients.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}