{{Rsnum
|rsid=6138150
|Chromosome=20
|position=23866372
|Orientation=plus
|GMAF=0.2172
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 1.8 | 30.1 | 68.1
| HCB | 9.6 | 45.2 | 45.2
| JPT | 12.5 | 42.9 | 44.6
| YRI | 1.4 | 25.9 | 72.8
| ASW | 1.8 | 26.3 | 71.9
| CHB | 9.6 | 45.2 | 45.2
| CHD | 14.7 | 37.6 | 47.7
| GIH | 4.0 | 27.7 | 68.3
| LWK | 2.7 | 24.5 | 72.7
| MEX | 0.0 | 37.9 | 62.1
| MKK | 0.0 | 17.3 | 82.7
| TSI | 2.0 | 24.5 | 73.5
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=18615156
|Trait=Treatment response to TNF antagonists
|Title=Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in Rheumatoid Arthritis
|RiskAllele=T
|Pval=0.0000030000000000000001
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PharmGKB
|RSID=rs6138150
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18615156
|Annotation=This variant is significantly associated with the efficacy of anti-TNF treatment in rheumatoid arthritis (Adjusted P-value: 0.000003; OR: 11.1 (2.5, 103.3)). The study is a genome-wide association study using the Illumina HapMap300 SNP chip on 89 RA patients prospectively followed after beginning of anti-TNF therapy.
|Drugs=adalimumab; etanercept; infliximab
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA162928832
}}

{{PMID Auto
|PMID=20423481
|Title=Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6138150
|overall_frequency_n=16
|overall_frequency_d=124
|overall_frequency=0.129032
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=11
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}