{{Rsnum
|rsid=613872
|Gene=TCF4
|Chromosome=18
|position=55543071
|Orientation=plus
|GMAF=0.0831
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=TCF4
}}[[rs613872]] is an intronic SNP in the transcription factor 4 [[TCF4]] gene on ch18q21.2.

{{PMID|20825314}} This GWAS study reported in 2010 the association between several independent [[TCF4]] SNPs and [[Fuchs' dystrophy]], including [[rs613872]]. They estimated the population attributable risk at about 60% for the [[rs613872]] risk genotypes; in other words, barring other interactions, the relatively common minor allele [[rs613872]](G) is associated with over half of all reported cases of Fuchs' dystrophy in the patient group studied. That does not mean it is causative, though; after all, ~30% of the CEU population carries this allele but the fraction developing Fuchs' dystrophy is less than 5%, so most [[rs613872]](G) carriers are not diagnosed with the disorder.

{{PMID|24270849|OA=1
}} [[rs613872]] was found to be associated with [[Fuchs' dystrophy]] based on a study by the eMERGE network in which electronic medical records were searched to find clinical associations associated with selected SNPs.
{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 5.3 | 27.4 | 67.3
| HCB | 0.0 | 1.5 | 98.5
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 12.3 | 87.7
| CHB | 0.0 | 1.5 | 98.5
| CHD | 0.0 | 0.0 | 0.0
| GIH | 1.0 | 16.8 | 82.2
| LWK | 0.0 | 0.0 | 0.0
| MEX | 3.4 | 12.1 | 84.5
| MKK | 0.0 | 1.9 | 98.1
| TSI | 4.9 | 30.4 | 64.7
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=20825314
|Trait=None
|Title=E2-2 protein and Fuchs's corneal dystrophy
|RiskAllele=G
|Pval=1E-18
|OR=5.47
|ORtxt=[3.75-7.99]
}}

{{PMID Auto
|PMID=21245398
|Title=Replication of the TCF4 Intronic Variant in Late-Onset Fuchs Corneal Dystrophy and Evidence of Independence from the FCD2 locus
|OA=1
}}

{{omim
|id=613267
|rsnum=613872
}}

{{PMID Auto
|PMID=21659310
|Title=Association of TCF4 Gene Polymorphisms with Fuchs Corneal Dystrophy in the Chinese
}}

{{PMID Auto
|PMID=22146553
|Title=Role of the TCF4 Gene Intronic Variant in Normal Variation of Corneal Endothelium
}}

{{PMID Auto
|PMID=22234156
|Title=Association of TCF4 and CLU polymorphisms with Fuchs' endothelial dystrophy and implication of CLU and TGFBI proteins in the disease process.
|OA=1
}}

{{PMID Auto
|PMID=22321803
|Title=Prevalence and severity of fuchs corneal dystrophy in Tangier Island.
}}

{{PMID Auto
|PMID=24255041
|Title=Association and Familial Segregation of CTG18.1 Trinucleotide Repeat Expansion of TCF4 Gene in Fuchs' Endothelial Corneal Dystrophy
}}

{{PMID Auto
|PMID=22998502
|Title=Confirmation of the association between the TCF4 risk allele and Fuchs endothelial corneal dystrophy in patients from the Midwestern United States.
}}

[[rs17595731]] is notable since variation here was observed in a SNPedia user with a family history of [[Fuchs' dystrophy]]. That location is not on any microarrays.

{{PMID Auto
|PMID=24917144
|Title=Mitochondrial Polymorphism A10398G and Haplogroup I are associated with Fuchs Endothelial Corneal Dystrophy
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}