{{Rsnum
|rsid=6152
|Gene=AR
|Chromosome=X
|position=67545785
|Orientation=plus
|ReferenceAllele=G
|GMAF=0.2146
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=baldness
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=AR
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 0.0 | 0.0
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 60.3 | 19.0 | 20.6
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs6152]], located in the first exon of the androgen receptor [[AR]] gene located on the X chromosome, is highly indicative of the ability to develop male pattern [[baldness]]. The risk allele is (G). However, although it appears to be necessary for [[baldness]] to develop, other (as yet unknown) variations must also be present for [[baldness]] to actually occur. {{PMID|11231320}}, {{PMID|17256155}}

Since this SNP is on the X chromosome, and affects a trait primarily seen only in males, a single allele is shown as representing the individual's genotype. However, [[baldness]] may also occur in females, presumably only in females homozygous for [[rs6152]](G;G) and also harboring the (as yet unknown) additional variations required for [[baldness]].

Note: The colorful and informative Figure 1 in {{PMID|17256155}} shows the probability of varying degrees of baldness as men age depending on whether they are [[rs6152(A)]] or [[rs6152(G)]].

Note: A subsequent study has found that [[rs1160312]] may be an important additional variant acting in conjunction with [[rs6152]] to influence [[baldness]].

{{PMID|15902657|OA=1
}}  [[baldness]]
*lowest P value of 2.1×10-12 for [[rs10521339]]
*family based [[rs938059]] shows the lowest P value (4.03×10-6) (table 3)
*[[rs6152]] (P=6.66×10-10)

{{omim
|desc=ALOPECIA, ANDROGENETIC, 2; AGA2
|id=300710
|rsnum=6152
}}

{{PMID Auto
|PMID=21981665
|Title=Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis
}}

{{PMID Auto
|PMID=15570555
|Title=Systematic evaluation of genetic variation at the androgen receptor locus and risk of prostate cancer in a multiethnic cohort study.
|OA=1
}}

{{PMID Auto
|PMID=15994977
|Title=Androgen receptor cytosine, adenine, guanine repeats, and haplotypes in relation to ovarian cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=16987421
|Title=A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3).
|OA=1
}}

{{PMID Auto
|PMID=18385763
|Title=EDA2R is associated with androgenetic alopecia.
}}

{{PMID Auto
|PMID=19167832
|Title=Possible association between the androgen receptor gene and autism spectrum disorder.
}}

{{PMID Auto
|PMID=19190146
|Title=Genetic variation in the androgen receptor gene and endometrial cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19555469
|Title=A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20450840
|Title=Association of AR rs6152G/A gene polymorphism with susceptibility to polycystic ovary syndrome in Chinese women.
}}

{{PMID Auto
|PMID=23441776
|Title=Androgen receptor genetic variants in male patients with ankylosing spondylitis in Taiwan
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}