{{Rsnum
|rsid=61736969
|Chromosome=13
|position=75324385
|Orientation=plus
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene=TBC1D4
|Gene_s=TBC1D4
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
}}Study [http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13425.html "A common Greenlandic [[TBC1D4]] variant confers muscle insulin resistance and type 2 diabetes"] found association with higher 2 hour plasma glucose (β = 3.8 mmol l−1, P = 2.5 × 10−35 homozygous) and serum insulin (β = 165 pmol l−1, P = 1.5 × 10−20 homozygous) and subset of diabetes that features deterioration of postprandial glucose homeostasis among Greenlandic population. Each minor allele of resulting p.Arg684Ter (Triallelic, stop gained allele A, MAF 17% in study) conferred increasingly lower levels of messenger RNA and protein levels of the long isoform of [[TBC1D4]] needed in skeletal muscle, and lower muscle protein levels of the glucose transporter [[GLUT4]].

[[rs7330796]], [[rs1062087]], [[rs2297206]] are in close [[linkage disequilibrium]] with this SNP[http://www.nature.com/nature/journal/vaop/ncurrent/fig_tab/nature13425_ST2.html], however they're much more common than this causal variant, which has so far been only found in those of Greenlandic descent. A genotyping panel with [[rs7330796]] was used for discovery of this variant.