{{Rsnum
|rsid=61757781
|Gene=PSEN2
|Chromosome=1
|position=226888112
|Orientation=plus
|Summary=Mutation in the PSEN2 Gene
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=PSEN2
}}Met174Val (A > G)  mutation; unclear if pathogenic, it is included in the [http://www.molgen.ua.ac.be/ADMutations/Default.cfm?MT=1&ML=0&Page=Mutations&ID=450 Alzheimer Disease & Frontotemporal Dementia Mutation Database].

Clinical manifestation : early onset Alzheimer's Disease

Early literature classified this as pathogenic, the latest ones cast some doubts.

{{PMID|18667258|OA=1
}} Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP.

{{PMID|22312439|OA=1
}} Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families.

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}