{{Rsnum
|rsid=619203
|Gene=ROS1
|Chromosome=6
|position=117301021
|Orientation=minus
|GMAF=0.1598
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=ROS1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 96.9 | 3.1 | 0.0
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}The G->C (Cys2229Ser) polymorphism ([[rs619203]]) of the [[ROS1]] gene was significantly associated with atherothrombotic cerebral infarction in a study of 3,400+ Japanese adults.{{PMID|18566305}}

An independent study of 3657 patients with myocardial infarction (885 women and 2772 men) and 1211 control individuals (598 women and 613 men) did not observe any correlation to this SNP.{{PMID|19709766}}

rs619203 increases susceptibility to Myocardial Infarction 1.15 times for heterozygotes (CG) and 1.75 times for homozygotes (TT) {{PMID|16175505|OA=1
}}
{{Venter SNP
|rsid=619203
|allele=C
|frequency=0.25
|uid=1103652977666
|type=homozygous_SNP
|hugo=ROS1
|ensembl gene=ENSG00000047936
|ensembl transcript=ENST00000368508
|sift=
|disease=A chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM). An homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.
}}
{{ neighbor
| rsid = 529156
| distance = 4
}}

{{PMID Auto
|PMID=22856164
|Title=[Evaluation of association between 9 genetic polymorphism and myocardial infarction in the Siberian population]
}}

{{PMID|18599554|OA=1
}} Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia.

{{PMID|19863298}} ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study.

{{GET Evidence
|gene=ROS1
|aa_change=Ser2229Cys
|aa_change_short=S2229C
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs619203
|overall_frequency_n=2133
|overall_frequency_d=10758
|overall_frequency=0.198271
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=22
|n_articles=0
|n_articles_annotated=0
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=24087953
|Title=[Genetic predictors of myocardial infarction in subjects of young age]
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}