{{Rsnum
|rsid = 6195
|Gene = NR3C1
|Chromosome = 5
|position=143399752
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Orientation=plus
|Gene_s=NR3C1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Status = Merged
|Merged = 56149945
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 93.8 | 6.2 | 0.0
| HCB | 99.3 | 0.7 | 0.0
| JPT | 0.0 | 0.0 | 0.0
| YRI | 0.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 97.0 | 3.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 98.3 | 1.7 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[[rs6195]] (Asn363Ser/N363S) is a SNP within the [[NR3C1]] (Nuclear receptor subfamily 3, group C, member 1 [glucocorticoid receptor]) gene. The common A allele encodes for Asparagine and the less common G allele encodes for Serine.

[http://jcem.endojournals.org/cgi/content/abstract/92/8/3268 Abstract] linked to increased glucocorticoid sensitivity, coronary artery disease, and increased body mass index.

{{omim
| id = 138040
| variant = 0007
| desc    = GLUCOCORTICOID RECEPTOR POLYMORPHISM
| rsnum   = 6195
}}

{{PMID Auto
|PMID=20472303
|Title=Associations between common arginine vasopressin 1b receptor and glucocorticoid receptor gene variants and HPA axis responses to psychosocial stress in a child psychiatric population
}}
{{PMID Auto
|PMID=20547006
|Title=FKBP5 and resistant attachment predict cortisol reactivity in infants: Gene-environment interaction
}}

{{PMID Auto
|PMID=22507373
|Title=Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men
}}

{{PMID|17535992|OA=1
}} Molecular evidence for a link between the N363S glucocorticoid receptor polymorphism and altered gene expression.

{{PMID|18854398|OA=1
}} Glucocorticoid receptor gene variant in the 3' untranslated region is associated with multiple measures of blood pressure.

{{PMID|18952539}} No association of glucocorticoid receptor polymorphisms with asthma and response to glucocorticoids.

{{PMID|19673019|OA=1
}} IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.

{{PMID|20015871|OA=1
}} Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia.

{{PMID|20199670|OA=1
}} Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study.

{{PMID|20592916|OA=1
}} Pharmacogenomic approaches to asthma treatment.

{{PMID|21448414|OA=1
}} Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.

{{PMID|21803757}} Genetic polymorphisms of the glucocorticoid receptor may affect the phenotype of women with anovulatory polycystic ovary syndrome.

{{PMID|21876507}} Glucocorticoid receptor polymorphism is associated with lithium response in bipolar patients.

{{PMID Auto
|PMID=22781842
|Title=Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}