{{Rsnum
|rsid=6198
|Gene=NR3C1
|Chromosome=5
|position=143278056
|Orientation=plus
|GMAF=0.09229
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=NR3C1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 62.8 | 34.5 | 2.7
| HCB | 99.3 | 0.7 | 0.0
| JPT | 0.0 | 0.0 | 0.0
| YRI | 92.5 | 6.8 | 0.7
| ASW | 89.5 | 10.5 | 0.0
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 71.3 | 25.7 | 3.0
| LWK | 93.6 | 6.4 | 0.0
| MEX | 81.0 | 19.0 | 0.0
| MKK | 76.9 | 20.5 | 2.6
| TSI | 56.9 | 37.3 | 5.9
| HapMapRevision=28
}}

[[rs6198]] (A3669G) is a SNP located within exon 9 beta of the NR3C1 (Nuclear receptor subfamily 3, group C, member 1 [glucocorticoid receptor]) gene.

{{PMID|18663733}}  [[rs10482605]](C) and [[rs6198]] form a haplotype responsible for both regulation of glucocorticoid expression and mRNA stability and therefore theorized to be associated with major [[depression]].

[http://jcem.endojournals.org/cgi/content/abstract/94/1/268 journal] significant [[blood pressure]] associations of a haplotype that is distinguished by rs6198 A/G.

{{PMID Auto
|PMID=20440229
|Title=Glucocorticoid receptor gene polymorphisms in Italian patients with eating disorders and obesity
}}
{{PMID Auto
|PMID=20547006
|Title=FKBP5 and resistant attachment predict cortisol reactivity in infants: Gene-environment interaction
}}

{{PMID Auto
|PMID=21164266
|Title=Glucocorticoid resistance
}}

{{PMID Auto
|PMID=22507373
|Title=Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men
}}

{{PMID Auto
|PMID=18830906
|Title=Glucocorticoid receptor variants may predispose to rheumatoid arthritis susceptibility.
}}

{{PMID|17532759|OA=1
}} Glucocorticoid receptor gene polymorphisms and susceptibility to rheumatoid arthritis.

{{PMID|18854398|OA=1
}} Glucocorticoid receptor gene variant in the 3' untranslated region is associated with multiple measures of blood pressure.

{{PMID|20199670|OA=1
}} Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study.

{{PMID|20680430|OA=1
}} No associations between single nucleotide polymorphisms in corticoid receptor genes and heart rate and cortisol responses to a standardized social stress test in adolescents: the TRAILS study.

{{PMID|21146942}} Glucocorticoid receptor-9beta polymorphism is associated with systolic blood pressure and heart growth during early childhood. The Generation R Study.

{{PMID|21232135|OA=1
}} Glucocorticoid receptor gene polymorphism and juvenile idiopathic arthritis.

{{PMID|21448414|OA=1
}} Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.

{{PMID|21764460}} Glucocorticoid receptor polymorphism is associated with major depression and predominance of depression in the course of bipolar disorder.

{{PMID|21803757}} Genetic polymorphisms of the glucocorticoid receptor may affect the phenotype of women with anovulatory polycystic ovary syndrome.

{{PMID|21876507}} Glucocorticoid receptor polymorphism is associated with lithium response in bipolar patients.

{{PMID|22083731}} Genetic modulation of neural response during working memory in healthy individuals: interaction of glucocorticoid receptor and dopaminergic genes.

{{PMID Auto
|PMID=22781842
|Title=Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior
|OA=1
}}

{{PMID Auto
|PMID=23055001
|Title=Genetic evidence for the association of the hypothalamic-pituitary-adrenal (HPA) axis with ADHD and methylphenidate treatment response.
}}

{{PMID Auto
|PMID=23543128
|Title=MR and GR functional SNPs may modulate tobacco smoking susceptibility.
}}

{{PMID Auto
|PMID=24856550
|Title=FKBP5 polymorphism is associated with major depression but not with bipolar disorder
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}