{{Rsnum
|rsid=6259
|Gene=SHBG
|Chromosome=17
|position=7633209
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.08724
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SHBG
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 4.4 | 19.5 | 76.1
| HCB | 4.4 | 28.5 | 67.2
| JPT | 2.7 | 19.5 | 77.9
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 7.0 | 93.0
| CHB | 4.4 | 28.5 | 67.2
| CHD | 0.9 | 17.4 | 81.7
| GIH | 0.0 | 12.9 | 87.1
| LWK | 0.0 | 1.8 | 98.2
| MEX | 0.0 | 6.9 | 93.1
| MKK | 0.0 | 5.8 | 94.2
| TSI | 2.0 | 15.7 | 82.4
| HapMapRevision=28
}}[[rs6259]], also known as Asp327Asn, is a SNP in the sex hormone-binding globulin [[SHBG]] gene. The [[rs6259]](G) allele encodes the Asp, while the [[rs6259]](A) allele encodes the Asn.

[[rs6259]] was associated with decreased risk of [[endometrial cancer]],  particularly among postmenopausal women (odds ratio 0.79, CI: 0.62-1.00), in a case-control study of 1,199 endometrial cancer patients and 1,212 controls. There was an inverse association of soy intake and tea consumption being more evident for those with the [[rs6259]](G;G) genotype, particularly premenopausal women (P(interaction) = 0.06 and 0.02, respectively, for soy isoflavones and tea intake). In other words, premenopausal [[rs6259]](G;G) women have reduced risk for [[endometrial cancer]] when they intake more soy and consume more tea.{{PMID|19005973|OA=1
}}

{{PMID Auto
|PMID=19168589
|Title=Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China
|OA=1
}}

{{PMID Auto
|PMID=19657112
|Title=Sex Hormone-Binding Globulin and Risk of Type 2 Diabetes in Women and Men
|OA=1
}}
{{PMID Auto
|PMID=19679209
|Title=Effects of Polymorphisms of the Sex Hormone-Binding Globulin (SHBG) Gene on Free Estradiol and Bone Mineral Density
|OA=1
}}

{{PMID Auto
|PMID=20432167
|Title=Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians
}} 

{{PMID|9435448}} Human variant sex hormone-binding globulin (SHBG) with an additional carbohydrate chain has a reduced clearance rate in rabbit  

{{omim
|id=125853
|rsnum=6259
}}

{{PMID|17411440|OA=1
}} Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study.

{{PMID|18603647|OA=1
}} Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

{{PMID|18628428|OA=1
}} Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.

{{PMID|18980759}} Polymorphisms of estrogen-related genes jointly confer susceptibility to human spermatogenic defect.

{{PMID|19015200|OA=1
}} Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer.

{{PMID|19064566|OA=1
}} Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women.

{{PMID|19649728}} Asp327Asn polymorphism of sex hormone-binding globulin gene is associated with systemic lupus erythematosus incidence.

{{PMID|20533011}} Serotonin-1A receptor gene polymorphism and the ability of antipsychotic drugs to improve attention in schizophrenia.

{{PMID|20616999|OA=1
}} Usefulness of Mendelian randomization in observational epidemiology.

{{PMID|21030499|OA=1
}} Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women.

{{PMID|21252242|OA=1
}} Polymorphisms in the SHBG gene influence serum SHBG levels in women with polycystic ovary syndrome.

{{PMID|21429951}} Quantitative trait analysis suggests polymorphisms of estrogen-related genes regulate human sperm concentrations and motility.

{{GET Evidence
|gene=SHBG
|aa_change=Asp356Asn
|aa_change_short=D356N
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6259
|overall_frequency_n=997
|overall_frequency_d=10758
|overall_frequency=0.0926752
|n_genomes=8
|n_genomes_annotated=0
|n_haplomes=8
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.003
|nblosum100=-1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=22633539
|Title=Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer.
|OA=1
}}

{{PMID Auto
|PMID=22711300
|Title=Association between SHBG Asp327Asn (rs6259) polymorphism and breast cancer risk: a meta-analysis of 10,454 cases and 13,111 controls.
}}

{{PMID Auto
|PMID=22936694
|Title=Genome-wide association study identifies a new locus JMJD1C at 10q21 that may influence serum androgen levels in men.
|OA=1
}}

{{PMID Auto
|PMID=23001781
|Title=Common variants in the sex hormone-binding globulin gene (SHBG) and polycystic ovary syndrome (PCOS) in Mediterranean women.
}}

{{PMID Auto
|PMID=23305451
|Title=Association of anthropometric, androgenic and insulin-related features with polymorphisms in exon 8 of SHBG gene in women with polycystic ovary syndrome.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}