{{Rsnum
|rsid=6265
|Gene=BDNF
|Chromosome=11
|position=27658369
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.2287
|Gene_s=BDNF,BDNF-AS
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 2.7 | 33.6 | 63.7
| HCB | 25.5 | 46.7 | 27.7
| JPT | 16.8 | 43.4 | 39.8
| YRI | 0.0 | 0.7 | 99.3
| ASW | 0.0 | 8.8 | 91.2
| CHB | 25.5 | 46.7 | 27.7
| CHD | 23.9 | 48.6 | 27.5
| GIH | 2.0 | 27.7 | 70.3
| LWK | 0.0 | 0.0 | 0.0
| MEX | 6.9 | 25.9 | 67.2
| MKK | 0.0 | 1.9 | 98.1
| TSI | 5.9 | 36.3 | 57.8
| HapMapRevision=28
}}
[[rs6265]], also known as Val66Met, is a SNP in brain-derived neurotrophic factor [[BDNF]] gene. The more common G allele encodes the Val, while the A allele encodes Met.

{{PMID|20042999|OA=1
}} Met/A allele associated with introversion

The A allele may also be protective against [[depression]] when subjected to repeated defeat {{PMID|17956738}} [http://genes2brains2mentalhealth.wordpress.com/2007/11/19/rs6265-a-is-my-bodyguard/ g2b2mh blog]

On a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. {{PMID|19745020|OA=1
}}

[http://www.wired.com/wiredscience/2009/10/genetically-bad-driving/ Wired] discusses the research as does [http://blog.23andme.com/2009/10/30/snpwatch-the-bad-driving-gene/ 23andMe blog].

{{PMID|17293537|OA=1
}} [[Alzheimer's disease]] risk for non [[ApoE4]] carriers is affected by the heterozygous form of [[rs6265]], as well as the diplotypes  of [[rs6265]], [[rs11030104]], and [[rs2049045]].

{{PMID|18600033}} Depressed patients who had (GA or AA) appeared to show a significantly increased risk of suicidal behaviour

{{PMID|19209189|OA=1
}} In 2 studies of British women, [[rs6265]](A;A) women had a lower body mass index than [[rs6265]](G) allele carriers, with the difference being -0.57-0.911 kg/m(2), depending on the study.

{{ neighbor
| rsid = 8192466
| distance = 191
}}

{{PMID Auto
|PMID=19388013
|Title=BDNF, relative preference, and reward circuitry responses to emotional communication
}}
{{PMID Auto GWAS
|PMID=19079260
|Trait=Body mass index
|Title=Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
|RiskAllele=G
|Pval=5E-10
|OR=4.58
|ORtxt=[3.07-6.09] % SD
}}
{{PMID Auto
|PMID=19461660
|Title=No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population
}}

{{PMID Auto
|PMID=19530966
|Title=Development of a new genotyping assay for detection of the BDNF Val66Met polymorphism using melting-curve analysis
}}

{{PMID Auto
|PMID=19603419
|Title=Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult [[ADHD]] in four European populations
}}

{{PMID Auto
|PMID=20943059
|Title=Attention-deficit hyperactivity disorder and intellectual disability: a study of association with brain-derived neurotrophic factor gene polymorphisms
}}

{{PMID Auto
|PMID=15940292
|Title=A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication
}}

{{PMID Auto
|PMID=18286632 
|Title=Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder
}}

{{omim
|id=113505
|desc=BRAIN-DERIVED NEUROTROPHIC FACTOR; BDNF
|rsnum=6265
}}
{{PMID Auto
|PMID=19699537
|Title=Family-based association study between brain-derived neurotrophic factor gene and major depressive disorder of Chinese descent
}}
{{PMID Auto
|PMID=19925205
|Title=Ebbinghaus Revisited: Influences of the BDNF Val66Met Polymorphism on Backward Serial Recall Are Modulated by Human Aging
}}

{{PharmGKB
|RSID=rs6265
|Name_s=
|Gene_s=BDNF
|Feature=
|Evidence=PubMed ID:19414708
|Annotation=This nonsynonymous variant (G/A) in an exon in BDNF gene was associated with major depressive disorder in a study of 264 controls and 272 Mexican Americans with major depressive disorder. (OR= 1.66; p value=0.009; risk allele=G)
|Drugs=
|Drug Classes=
|Diseases=Depression; Depressive Disorder, Major
|Curation Level=Curated
|PharmGKB Accession ID=PA164857051
}}
{{PMID Auto
|PMID=20033742
|Title=Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population
}}
{{PMID Auto
|PMID=19895626
|Title=The effect of BDNF gene variants on asthma in German children
}}

{{PMID Auto
|PMID=20087404
|Title=Genetic variants in the BDNF gene and therapeutic response to risperidone in schizophrenia patients: a pharmacogenetic study
|OA=1
}}

{{PMID Auto
|PMID=20147969
|Title=Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension
}}

{{PMID Auto
|PMID=20418890
|Title=Genome-wide meta-analyses identify multiple loci associated with smoking behavior
|OA=1
}}
{{PMID Auto
|PMID=20682308
|Title=The combined effects of the BDNF and GSK3B genes modulate the relationship between negative life events and major depressive disorder
}}
{{PMID Auto
|PMID=20456319
|Title=Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia
}}
{{PMID Auto
|PMID=20702703
|Title=The Role of the BDNF Val66Met Polymorphism for the Synchronization of Error-Specific Neural Networks
}}
{{PMID Auto
|PMID=20959432
|Title=BDNF and CGRP interaction: Implications in migraine susceptibility
}}
{{PMID Auto
|PMID=20966902
|Title=Genome-Wide Association Study of Anthropometric Traits and Evidence of Interactions With Age and Study Year in Filipino Women
|OA=1
}}

{{PharmGKB
|RSID=rs6265
|Name_s=BDNF:Val66Met
|Gene_s=BDNF
|Feature=
|Evidence=PubMed ID:18319075
|Annotation=In DNA from frontal-cortex brain tissue of a group of Schizophrenia, Bipolar Disorder and Control individuals, this SNP was found to be associated with methylation at CpG sites surrounding the gene. CC genotype was associated with a higher level of methylation.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA162364070
}}

{{PharmGKB
|RSID=rs6265
|Name_s=
|Gene_s=BDNF
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 11p14.1; Reported Gene(s): BDNF; Risk Allele: rs6265-G); (p-value= 0.0000000005).This variant is associated with Body mass index.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740154
}}

{{PharmGKB
|RSID=rs6265
|Name_s=
|Gene_s=BDNF
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 11p14.1; Reported Gene(s): BDNF; Risk Allele: rs6265-G); (p-value= 0.0000002).This variant is associated with Weight.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740174
}}
{{PMID Auto
|PMID=21188787
|Title=Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder
}}
{{PMID Auto
|PMID=20843981
|Title=Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children
|OA=1
}}

{{PMID Auto
|PMID=21300947
|Title=The Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Prediction of Neural Risk for Alzheimer Disease
}}

{{omim
|id=113505
|rsnum=6265
|variant=0002
}}

{{PMID Auto
|PMID=21723144
|Title=Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore
}}

{{PMID Auto
|PMID=21796141
|Title=Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
}}

{{PMID Auto
|PMID=21527513
|Title=Influence of physical inactivity on associations between single nucleotide polymorphisms and genetic predisposition to childhood obesity
}}

{{PMID Auto
|PMID=21889574
|Title=Association analysis between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and treatment response to venlafaxine XR in generalized anxiety disorder
}}

{{PMID Auto
|PMID=21980924
|Title=BDNF Val66Met and Cognition: All, None, or Some? A Meta-Analysis of the Genetic Association
|OA=1
}}

{{PMID Auto
|PMID=22033217
|Title=Interaction between BDNF Val66Met and childhood stressful life events is associated to affective memory bias in men but not women
}}

{{PMID Auto
|PMID=22085476
|Title=Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene
}}

{{PMID Auto
|PMID=22127997
|Title=No association of brain-derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese
}}

{{PMID Auto
|PMID=22173577
|Title=Recapitulation of the Association of the Val66Met Polymorphism of BDNF Gene With BMI in Koreans
}}

{{PMID Auto
|PMID=22188054
|Title=Polymorphisms in the Brain Derived Neurotrophic Factor (BDNF) Gene Influence Memory and Processing Speed One Month After Brain Injury
|OA=1
}}

{{PMID Auto
|PMID=22194877
|Title=Brain Derived Neurotrophic Factor (BDNF) Expression Is Regulated by MicroRNAs miR-26a and miR-26b Allele-Specific Binding
|OA=1
}}

{{PMID Auto
|PMID=21641949
|Title=Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in an Armenian population
}}

{{PMID Auto
|PMID=21880305
|Title=The brain-derived neurotrophic factor is associated with alcohol dependence-related depression and antidepressant response
}}

{{PMID Auto
|PMID=22548711
|Title=Association of BDNF Gene Polymorphism with Bipolar Disorders in Han Chinese Population
}}

{{PMID Auto
|PMID=22719849
|Title=Impact of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on Cortical Thickness and Voxel-Based Morphometry in Healthy Chinese Young Adults
|OA=1
}}

{{PMID Auto
|PMID=22766130
|Title=BDNF Val66Met and spontaneous dyskinesias in non-clinical psychosis
|OA=1
}}

{{ClinVar
|rsid=6265
|Reversed=1
|FwdREF=G
|FwdALT=A
|REF=C
|ALT=T
|RSPOS=27679916
|CHROM=11
|GMAF=0.2285
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x050168000000150517130100
|GENEINFO=BDNF-AS:497258; BDNF:627
|GENE_NAME=BDNF-AS; BDNF
|GENE_ID=497258; 627
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000011.9:g.27679916C>T
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=113505.0002
|CLNSIG=255
|CLNCUI=C1853220; CN071481
|CLNDBN=Memory impairment, susceptibility to; Obsessive-compulsive disorder, protection against; Anorexia nervosa 2; Bulimia nervosa 2; Bipolar affective disorder, susceptibility to; Parkinson disease, age at onset, susceptibility to
|Disease=Memory impairment; Obsessive-compulsive disorder; Anorexia nervosa 2; Bulimia nervosa 2; Bipolar affective disorder; Parkinson disease
|CLNACC=RCV000019267.1; RCV000019268.1; RCV000019269.1; RCV000019270.1; RCV000019271.1; RCV000019272.1
|Tags=RV;PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;MTP;OM
|CAF=0.7713; 0.2287
|CLNDSDB=MedGen; MedGen:OMIM; GeneReviews:MedGen
|CLNDSDBID=C1853221; C1853220:610269; NBK1223:CN071481
|COMMON=1
}}

{{PMID Auto
|PMID=12836135
|Title=Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder.
|OA=1
}}

{{PMID Auto
|PMID=15457498
|Title=Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder.
}}

{{PMID Auto
|PMID=16005437
|Title=Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression.
}}

{{PMID Auto
|PMID=16497333
|Title=No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults.
}}

{{PMID Auto
|PMID=16631352
|Title=No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population.
}}

{{PMID Auto
|PMID=16741941
|Title=Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate.
}}

{{PMID Auto
|PMID=16962786
|Title=Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease.
}}

{{PMID Auto
|PMID=17096834
|Title=No association between polymorphisms in the BDNF gene and age at onset in Huntington disease.
|OA=1
}}

{{PMID Auto
|PMID=17135278
|Title=Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.
|OA=1
}}

{{PMID Auto
|PMID=17196936
|Title=Brain-derived neurotrophic factor and risk of schizophrenia: an association study and meta-analysis.
}}

{{PMID Auto
|PMID=17212826
|Title=TAMGeS: a Three-array Method for Genotyping of SNPs by a dual-colour approach.
|OA=1
}}

{{PMID Auto
|PMID=17219016
|Title=No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD.
}}

{{PMID Auto
|PMID=17417060
|Title=Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder.
}}

{{PMID Auto
|PMID=17483451
|Title=Gene-gene interaction associated with neural reward sensitivity.
|OA=1
}}

{{PMID Auto
|PMID=17503330
|Title=A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=17602759
|Title=Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis.
}}

{{PMID Auto
|PMID=17632285
|Title=The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans.
|OA=1
}}

{{PMID Auto
|PMID=17656372
|Title=Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor.
}}

{{PMID Auto
|PMID=17657167
|Title=Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population.
}}

{{PMID Auto
|PMID=17894414
|Title=BDNF Val66Met variant and age of onset in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=17918236
|Title=Association study of the brain-derived neurotropic factor (BDNF) gene in attention deficit hyperactivity disorder.
}}

{{PMID Auto
|PMID=18205169
|Title=Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis.
}}

{{PMID Auto
|PMID=18478177
|Title=Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine.
}}

{{PMID Auto
|PMID=18534558
|Title=Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=18565990
|Title=Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=18698231
|Title=Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.
|OA=1
}}

{{PMID Auto
|PMID=18704161
|Title=Genetic variation in an individual human exome.
|OA=1
}}

{{PMID Auto
|PMID=18776599
|Title=Susceptibility genes for gentamicin-induced vestibular dysfunction.
|OA=1
}}

{{PMID Auto
|PMID=18813964
|Title=Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.
|OA=1
}}

{{PMID Auto
|PMID=18830724
|Title=Assessment of Alzheimer's disease case-control associations using family-based methods.
|OA=1
}}

{{PMID Auto
|PMID=18852698
|Title=Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity.
}}

{{PMID Auto
|PMID=18957941
|Title=Genome-wide association scan for five major dimensions of personality.
|OA=1
}}

{{PMID Auto
|PMID=19018231
|Title=Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder.
|OA=1
}}

{{PMID Auto
|PMID=19018715
|Title=Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients.
}}

{{PMID Auto
|PMID=19236730
|Title=Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant treatment response.
}}

{{PMID Auto
|PMID=19258022
|Title=Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network.
|OA=1
}}

{{PMID Auto
|PMID=19295238
|Title=Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families.
}}

{{PMID Auto
|PMID=19330778
|Title=Positive association between the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder in the Han Chinese population.
}}

{{PMID Auto
|PMID=19336781
|Title=Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes.
|OA=1
}}

{{PMID Auto
|PMID=19359258
|Title=Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.
|OA=1
}}

{{PMID Auto
|PMID=19412541
|Title=Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects.
|OA=1
}}

{{PMID Auto
|PMID=19424874
|Title=Effect of BDNF Val66Met polymorphism on digital working memory and spatial localization in a healthy Chinese Han population.
}}

{{PMID Auto
|PMID=19478790
|Title=The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
|OA=1
}}

{{PMID Auto
|PMID=19582215
|Title=Association study between BDNF gene polymorphisms and autism by three-dimensional gel-based microarray.
|OA=1
}}

{{PMID Auto
|PMID=19582565
|Title=Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder.
}}

{{PMID Auto
|PMID=19721723
|Title=Brain-derived neurotrophic factor: role in depression and suicide.
|OA=1
}}

{{PMID Auto
|PMID=19721846
|Title=Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants.
|OA=1
}}

{{PMID Auto
|PMID=19844571
|Title=Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities.
|OA=1
}}

{{PMID Auto
|PMID=19940176
|Title=Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans.
|OA=1
}}

{{PMID Auto
|PMID=19953912
|Title=[An association study of brain-derived neurotrophic factor gene polymorphism in bipolar disorders].
}}

{{PMID Auto
|PMID=20004415
|Title=Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene.
}}

{{PMID Auto
|PMID=20008943
|Title=Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.
|OA=1
}}

{{PMID Auto
|PMID=20014955
|Title=Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression.
}}

{{PMID Auto
|PMID=20016225
|Title=Association of brain-derived neurotrophic factor genetic Val66Met polymorphism with severity of depression, efficacy of fluoxetine and its side effects in Chinese major depressive patients.
}}

{{PMID Auto
|PMID=20127379
|Title=From monogenic to polygenic obesity: recent advances.
|OA=1
}}

{{PMID Auto
|PMID=20172611
|Title=Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder.
}}

{{PMID Auto
|PMID=20191112
|Title=The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives.
|OA=1
}}

{{PMID Auto
|PMID=20226536
|Title=Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort.
}}

{{PMID Auto
|PMID=20400928
|Title=Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR.
|OA=1
}}

{{PMID Auto
|PMID=20426150
|Title=Extending genetic linkage analysis to diffusion tensor images to map single gene effects on brain fiber architecture.
}}

{{PMID Auto
|PMID=20478698
|Title=Effect of Met66 allele of the BDNF rs6265 SNP on regional gray matter volumes in patients with multiple sclerosis: A voxel-based morphometry study.
}}

{{PMID Auto
|PMID=20482942
|Title=Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory.
}}

{{PMID Auto
|PMID=20493546
|Title=BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects.
|OA=1
}}

{{PMID Auto
|PMID=20574532
|Title=Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{PMID Auto
|PMID=21037213
|Title=Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.
|OA=1
}}

{{PMID Auto
|PMID=21049304
|Title=Influence of candidate genes on attention problems in children: a longitudinal study.
|OA=1
}}

{{PMID Auto
|PMID=21097659
|Title=Interaction effect of functional variants of the BDNF and DRD2/ANKK1 gene is associated with alexithymia in healthy human subjects.
}}

{{PMID Auto
|PMID=21103954
|Title=Association between C-281A and val66met functional polymorphisms of BDNF gene and risk of recurrent major depressive disorder in Polish population.
}}

{{PMID Auto
|PMID=21167606
|Title=The role of BDNF genetic polymorphisms in bipolar disorder with psychiatric comorbidities.
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{PMID Auto
|PMID=21215389
|Title=The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions.
}}

{{PMID Auto
|PMID=21305693
|Title=Age at onset of psychotic disorder: cannabis, BDNF Val66Met, and sex-specific models of gene-environment interaction.
}}

{{PMID Auto
|PMID=21458533
|Title=Polymorphisms of brain-derived neurotrophic factor associated with heroin dependence.
}}

{{PMID Auto
|PMID=21491204
|Title=Candidate-gene approach in posttraumatic stress disorder after urban violence: association analysis of the genes encoding serotonin transporter, dopamine transporter, and BDNF.
}}

{{PMID Auto
|PMID=21509595
|Title=Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system.
|OA=1
}}

{{PMID Auto
|PMID=21577214
|Title=BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects.
}}

{{PMID Auto
|PMID=21640793
|Title=Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients.
}}

{{PMID Auto
|PMID=21695421
|Title=Brain-derived neurotrophic factor (BDNF) gene: a gender-specific role in cognitive function during normal cognitive aging of the MEMO-Study?
|OA=1
}}

{{PMID Auto
|PMID=21745335
|Title=5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination.
|OA=1
}}

{{PMID Auto
|PMID=21875455
|Title=The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis.
}}

{{PMID Auto
|PMID=21898033
|Title=Brain-derived neurotrophic factor gene polymorphisms, neurotransmitter levels, and depressive symptoms in an elderly population.
|OA=1
}}

{{PMID Auto
|PMID=21931317
|Title=BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity.
|OA=1
}}

{{PMID Auto
|PMID=21956459
|Title=Association study of brain-derived neurotrophic factor gene polymorphisms and body weight change in schizophrenic patients under long-term atypical antipsychotic treatment.
}}

{{PMID Auto
|PMID=21996278
|Title=Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.
}}

{{PMID Auto
|PMID=22008662
|Title=The association of the alpha-5 subunit of the nicotinic acetylcholine receptor gene and the brain-derived neurotrophic factor gene with different aspects of smoking behavior.
}}

{{PMID Auto
|PMID=22094229
|Title=Influence of BDNF variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia.
}}

{{PMID Auto
|PMID=22179955
|Title=Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.
|OA=1
}}

{{PMID Auto
|PMID=22585743
|Title=Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype.
}}

{{PMID Auto
|PMID=22609366
|Title=Neurotrophic Tyrosine Kinase Polymorphism Impacts White Matter Connections in Patients with Major Depressive Disorder.
}}

{{PMID Auto
|PMID=22610920
|Title=The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis.
|OA=1
}}

{{PMID Auto
|PMID=22642961
|Title=The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain.
}}

{{PMID Auto
|PMID=22965830
|Title=No influence of brain-derived neurotrophic factor (BDNF) polymorphisms on treatment response in a naturalistic sample of patients with major depression
}}

{{PMID Auto
|PMID=22615781
|Title=Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study
|OA=1
}}

{{GET Evidence
|gene=BDNF
|aa_change=Val81Met
|aa_change_short=V81M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6265
|overall_frequency_n=15
|overall_frequency_d=128
|overall_frequency=0.117188
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=15
|n_articles=0
|n_articles_annotated=0
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23170235
|Title=BDNF Val66Met polymorphism interacts with sex to influence bimanual motor control in healthy humans
|OA=1
}}

{{PMID Auto
|PMID=23269345
|Title=BDNF Val66Met homozygosity does not influence plasma BDNF levels in healthy human subjects
}}

{{PMID Auto
|PMID=23341118
|Title=Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume
}}

{{PMID Auto
|PMID=22910404
|Title=Genetic association study of the P300 endophenotype in schizophrenia
}}

{{PMID Auto
|PMID=23482723
|Title=Association between the BDNF Val66Met Polymorphism and Chronicity of Depression
|OA=1
}}

{{PMID Auto
|PMID=23487199
|Title=BDNF val66met Polymorphism Is Associated With Age at Onset and Intensity of Symptoms of Paranoid Schizophrenia in a Polish Population
}}

{{PMID Auto
|PMID=23628854
|Title=FTO predicts weight regain in the Look AHEAD clinical trial
}}

{{PMID Auto
|PMID=23712400
|Title=SNP rs6265 Regulates Protein Phosphorylation and Osteoblast Differentiation and Influences BMD in Humans
}}

{{PMID Auto
|PMID=23923080
|Title=Association of the brain-derived neurotrophic factor gene G196A rs6265 polymorphisms and the cognitive function and clinical symptoms of schizophrenia
|OA=1
}}

{{PMID Auto
|PMID=23424664
|Title=Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children
|OA=1
}}

{{PMID Auto
|PMID=23999029
|Title=Association study between BDNF gene variants and Mexican patients with obsessive-compulsive disorder
}}

{{PMID Auto
|PMID=23433505
|Title=Genetic variation in BDNF is associated with antipsychotic treatment resistance in patients with schizophrenia
|OA=1
}}

{{PMID Auto
|PMID=24198753
|Title=Toward a unified biological hypothesis for the BDNF Val66Met-associated memory deficits in humans: a model of impaired dendritic mRNA trafficking
|OA=1
}}

{{PMID Auto
|PMID=24269186
|Title=An obesity genetic risk score is associated with metabolic syndrome in Chinese children
}}

{{PMID Auto
|PMID=24399714
|Title=BDNF rs 6265 polymorphism and COMT rs 4680 polymorphism in deficit schizophrenia in Polish sample
}}

{{PMID Auto
|PMID=24567226
|Title=Brain-derived neurotrophic factor: its impact upon neuroplasticity and neuroplasticity inducing transcranial brain stimulation protocols
}}

{{PMID Auto
|PMID=23408508
|Title=Obesity-susceptibility loci and the tails of the pediatric BMI distribution
|OA=1
}}

{{PMID Auto
|PMID=22813992
|Title=Effect of BDNF val(66)met polymorphism on declarative memory and its neural substrate: a meta-analysis.
}}

{{PMID Auto
|PMID=22844024
|Title=Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol levels as a predictor of depression in adult women.
|OA=1
}}

{{PMID Auto
|PMID=22846907
|Title=Analysis of four genes involved in the neurodevelopment shows association of rs4307059 polymorphism in the cadherin 9/10 region with completed suicide.
}}

{{PMID Auto
|PMID=22989210
|Title=Brain-derived neurotrophic factor genotype is associated with brain gray and white matter tissue volumes recovery in abstinent alcohol-dependent individuals.
}}

{{PMID Auto
|PMID=23023098
|Title=Brain-derived neurotrophic factor Val66Met polymorphism and alcohol-related phenotypes.
}}

{{PMID Auto
|PMID=23062292
|Title=The brain-derived neurotrophic factor Val66Met polymorphism moderates early deprivation effects on attention problems.
|OA=1
}}

{{PMID Auto
|PMID=23137999
|Title=The role of BDNF, NTRK2 gene and their interaction in development of treatment-resistant depression: data from multicenter, prospective, longitudinal clinic practice.
|OA=1
}}

{{PMID Auto
|PMID=23184535
|Title=No association of genetic variants in BDNF with major depression: a meta- and gene-based analysis.
|OA=1
}}

{{PMID Auto
|PMID=23303061
|Title=Brain-derived neurotrophic factor serum levels and genotype: association with depression during interferon-alpha treatment.
|OA=1
}}

{{PMID Auto
|PMID=23461616
|Title=Association between brain-derived neurothropic factor variants and asthma in Chinese Han children.
}}

{{PMID Auto
|PMID=23643991
|Title=Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults.
}}

{{PMID Auto
|PMID=23733030
|Title=Pharmacogenetics in major depression: a comprehensive meta-analysis.
}}

{{PMID Auto
|PMID=23832605
|Title=Association of BDNF gene polymorphisms with schizophrenia and clinical symptoms in a Chinese population.
}}

{{PMID Auto
|PMID=24863266
|Title=Val66Met polymorphism in the BDNF gene in children with bronchial asthma
}}

{{PMID Auto
|PMID=24993285
|Title=BDNF SNPs Are Implicated in Comorbid Alcohol Dependence in Schizophrenia But Not in Alcohol-Dependent Patients Without Schizophrenia
}}

{{PMID Auto
|PMID=25044977
|Title=BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields
}}

{{PMID Auto
|PMID=25052186
|Title=Combined effects of the BDNF rs6265 (Val66Met) polymorphism and environment risk factors on psoriasis vulgaris
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}