{{Rsnum
|rsid=6267
|Gene=COMT
|Chromosome=22
|position=19962740
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=T
|GMAF=0.01699
|Gene_s=COMT,MIR4761
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 98.1 | 1.9 | 0.0
| HCB | 86.4 | 12.1 | 1.5
| JPT | 88.1 | 11.9 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 96.4 | 3.6 | 0.0
| CHB | 86.4 | 12.1 | 1.5
| CHD | 94.4 | 5.6 | 0.0
| GIH | 99.0 | 1.0 | 0.0
| LWK | 90.7 | 9.3 | 0.0
| MEX | 87.0 | 13.0 | 0.0
| MKK | 96.1 | 3.9 | 0.0
| TSI | 98.0 | 2.0 | 0.0
| HapMapRevision=28
}}{{omim
|desc=SCHIZOPHRENIA, SUSCEPTIBILITY TO
|id=116790
|rsnum=6267
|variant=0002
}}

{{ neighbor
| rsid = 4633
| distance = 28
}}
{{ neighbor
| rsid = 4818
| distance = 944
}}

{{PMID Auto
|PMID=19365560
|Title=Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs
|OA=1
}}
{{PMID Auto
|PMID=19881467
|Title=Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality
}}

{{PharmGKB
|RSID=rs6267
|Name_s=COMT: Ala72Ser
|Gene_s=COMT
|Feature=Exon/NonSyn
|Evidence=PubMed ID:18163386
|Annotation=This study showed a highly significant association between a COMT haplotype of two functional SNPs (Ala72Ser and Val158Met) and aggressive behavior in schizophrenia.
|Drugs=
|Drug Classes=
|Diseases=Schizophrenia
|Curation Level=Curated
|PharmGKB Accession ID=PA164944058
}}

{{ClinVar
|rsid=6267
|Reversed=0
|FwdREF=G
|FwdALT=T
|REF=G
|ALT=T
|RSPOS=19950263
|CHROM=22
|GMAF=0.0174
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x050378000000150517110101
|GENEINFO=COMT:1312; MIR4761:100616414
|GENE_NAME=COMT; MIR4761
|GENE_ID=1312; 100616414
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000022.10:g.19950263G>T
|CLNORIGIN=0
|CLNSIG=255
|Tags=PM;TPA;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.983; 0.01699
|CLNACC=RCV000019157.1
|CLNDBN=Schizophrenia, susceptibility to
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=116790.0002
|COMMON=1
|Disease=Schizophrenia
}}

{{PMID Auto
|PMID=15645182
|Title=Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans.
}}

{{PMID Auto
|PMID=17363961
|Title=Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.
}}

{{PMID Auto
|PMID=17482701
|Title=No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.
}}

{{PMID Auto
|PMID=19329282
|Title=Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.
}}

{{PMID Auto
|PMID=21342622
|Title=[Catechol-O-methyltransferase gene rs6267 polymorphism in children with attention deficit hyperactivity disorder].
}}

{{PMID Auto
|PMID=21462137
|Title=[An association study of COMT gene polymorphisms with schizophrenia].
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}