{{Rsnum
|rsid=6269
|Gene=COMT
|Chromosome=22
|position=19962429
|Orientation=plus
|GMAF=0.3719
|Gene_s=COMT,MIR4761
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{PMID Auto
|PMID=19290789
|Title=Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment
}}

{{PMID Auto
|PMID=19605537
|Title=Effects of Catechol-O-Methyltransferase on Normal Variation in the Cognitive Function of Children
|OA=1
}}

{{PharmGKB
|RSID=rs6269
|Name_s=
|Gene_s=COMT
|Feature=Intron
|Evidence=PubMed ID:15537663
|Annotation=On the basis of subjects' pain responsiveness, haplotypes involving rs6269 (A/G), rs4633 (C/T), rs4818 (C/G), and rs4680 (G/A) were designated as low (low pain sensitivity (LPS) haplotype; GCGG), average (average pain sensitivity (APS) haplotype; ATCA), or high (high pain sensitivity (HPS) haplotype; ACCG) pain sensitive.
|Drugs=
|Drug Classes=
|Diseases=Pain
|Curation Level=Curated
|PharmGKB Accession ID=PA164944059
}}

{{PMID Auto
|PMID=20570835
|Title=No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain
}}

{{PMID Auto
|PMID=21300128
|Title=COMT Val158met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa
}}

{{PMID Auto
|PMID=21884617
|Title=Association of COMT genotypes with S-COMT promoter methylation in growth-discordant monozygotic twins and healthy adults
|OA=1
}}

{{PMID Auto
|PMID=21940152
|Title=The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study
}}

{{PMID Auto
|PMID=22451510
|Title=Catechol-O-Methyltransferase Gene and Executive Function in Children With ADHD
}}

{{PMID Auto
|PMID=22528689
|Title=Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene
}}

{{PMID Auto
|PMID=22178088
|Title=Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome
|OA=1
}}

{{PMID Auto
|PMID=16848906
|Title=Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans.
|OA=1
}}

{{PMID Auto
|PMID=17961261
|Title=Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.
|OA=1
}}

{{PMID Auto
|PMID=18574484
|Title=The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.
|OA=1
}}

{{PMID Auto
|PMID=18698234
|Title=The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications.
}}

{{PMID Auto
|PMID=18802928
|Title=Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.
}}

{{PMID Auto
|PMID=19094200
|Title=Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain.
|OA=1
}}

{{PMID Auto
|PMID=19193196
|Title=Genetic contributions to pain: a review of findings in humans.
|OA=1
}}

{{PMID Auto
|PMID=19772600
|Title=A comparison of classification methods for predicting Chronic Fatigue Syndrome based on genetic data.
|OA=1
}}

{{PMID Auto
|PMID=20531207
|Title=The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.
}}

{{PMID Auto
|PMID=20627703
|Title=The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.
}}

{{PMID Auto
|PMID=20842020
|Title=Catecholamine-o-methyltransferase polymorphisms are associated with postoperative pain intensity.
}}

{{PMID Auto
|PMID=20863768
|Title=Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease.
}}

{{PMID Auto
|PMID=21304959
|Title=Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.
|OA=1
}}

{{PMID Auto
|PMID=21355050
|Title=A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2).
|OA=1
}}

{{PMID Auto
|PMID=21423693
|Title=Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures.
|OA=1
}}

{{PMID Auto
|PMID=21462137
|Title=[An association study of COMT gene polymorphisms with schizophrenia].
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6269
|overall_frequency_n=49
|overall_frequency_d=128
|overall_frequency=0.382812
|n_genomes=33
|n_genomes_annotated=0
|n_haplomes=42
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22890010
|Title=Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease.
}}

{{PMID Auto
|PMID=23178897
|Title=The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.
|OA=1
}}

{{PMID Auto
|PMID=24593143
|Title=Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}