{{Rsnum
|rsid=627441
|Gene=DLAT
|Chromosome=11
|position=112037438
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.483
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=DLAT
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 51.3 | 40.7 | 8.0
| HCB | 9.5 | 55.5 | 35.0
| JPT | 12.4 | 50.4 | 37.2
| YRI | 4.1 | 23.8 | 72.1
| ASW | 7.0 | 36.8 | 56.1
| CHB | 9.5 | 55.5 | 35.0
| CHD | 16.5 | 45.9 | 37.6
| GIH | 37.6 | 52.5 | 9.9
| LWK | 3.6 | 28.2 | 68.2
| MEX | 39.7 | 44.8 | 15.5
| MKK | 10.3 | 37.2 | 52.6
| TSI | 43.1 | 48.0 | 8.8
| HapMapRevision=28
}}

{{Venter SNP
|rsid=627441
|allele=C
|frequency=0.258
|uid=1103649792845
|type=homozygous_SNP
|hugo=DLAT
|ensembl gene=ENSG00000150768
|ensembl transcript=ENST00000280346
|sift=TOLERATED
|disease=Primary biliary cirrhosis is a chronic, progressive cholestatic liver disease characterized by the presence of antimitochondrial autoantibodies in patients' serum. It manifests with inflammatory obliteration of intra-hepatic bile duct, leading to liver cell damage and cirrhosis. Patients with primary biliary cirrhosis show autoantobodies againts the E2 component of pyruvate dehydrogenase complex.
}}

{{GET Evidence
|gene=DLAT
|aa_change=Val318Ala
|aa_change_short=V318A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs627441
|overall_frequency_n=5396
|overall_frequency_d=10758
|overall_frequency=0.50158
|n_genomes=46
|n_genomes_annotated=0
|n_haplomes=68
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=2
|autoscore=2
|n_web_uneval=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}